Sarah Morin, Filippo Boroli, Sophie Vandenberghe-Durr, Daniele Allali, Stavroula Masouridi-Levrat, Yves Chalandon, Federico Simonetta
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引用次数: 0
摘要
嵌合抗原受体 T(CAR-T)细胞输注时发生的过敏反应是关键临床试验或真实世界系列研究中尚未报道的不良事件。我们报告了一例在注射替沙格列脲治疗弥漫性大 B 细胞淋巴瘤后出现严重过敏性休克并伴有心脏骤停的患者,该患者在经过抢救和重症监护治疗后恢复了健康;我们还对食品药品管理局不良事件报告系统数据库进行了分析,发现了多例在注射 CAR-T 细胞后出现严重过敏性休克的病例。虽然在关键的CAR-T细胞研究中没有报道,但注射CAR-T细胞后可能会发生过敏性休克,这突出表明在未来的研究中需要将过敏性休克作为一种可能的副作用。
Severe anaphylaxis after chimeric antigen receptor T-cell injection: a case report
Anaphylactic reactions at the time of chimeric antigen receptor T (CAR-T) cell infusion are adverse events that have not been reported in pivotal clinical trials or in real-world series. We report the case of patient with severe anaphylaxis with cardiac arrest after tisagenlecleucel injection for Diffuse Large B cell Lymphoma, who recovered after resuscitation and intensive care treatment; we also conducted a Food and Drug Administration Adverse Event Reporting System database analysis and found several cases of severe anaphlyaxis after CAR-T cell injection. Although not reported in pivotal CAR-T cell studies, anaphylaxis can occur after CAR-T cell injection, highlighting the need to include anaphylaxis as a possible side effect in future studies.