液体活检是子宫内膜癌的新时代

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-19 DOI:10.1515/oncologie-2024-0036

Drenushe Zhuri, S. Yalçıntepe

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引用次数: 0

摘要

子宫内膜癌（EC）是女性生殖道最常见的浸润性癌症之一，尽管全世界的EC发病率不断上升，而且患者的总生存率很低，但目前还没有可行的基于血液的生物标志物来检测和跟踪常规随访期间的EC复发情况。确定与复发风险和药物反应增强相关的新基因靶点和生物标志物是治疗晚期子宫内膜癌的首要临床问题。在这方面，液体活检已成为人类癌症领域的一项突破。液体活检血液检测的优势在于比传统成像技术更灵敏，是对针刺或切除活检组织的微创补充。在本文中，我们讨论了液体活检的先进性和局限性。液体活检中生物标记物和变异的检测可能有助于子宫内膜癌病例的诊断过程。

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Liquid biopsy as a new era in endometrial cancer

Endometrial cancer (EC) is one of the most frequent invasive cancers of the female genital tract, and despite the rising incidence of EC worldwide and the poor overall survival of patients, no viable blood-based biomarker exists to detect and track EC recurrence during routine follow-up. Identification of new genetic targets and biomarkers linked to enhanced recurrence risk and medication response is a primary clinical issue in the treatment of advanced endometrial cancer. In this regard, liquid biopsy has become a breakthrough in human cancers. A liquid biopsy blood test has the advantage of being more sensitive than traditional imaging and is a minimally invasive complement to needle or excision biopsies of tissue. Here in this article, we discussed the advances and limitations of liquid biopsy. The detection of biomarkers and variations in liquid biopsy may help the diagnostic process of endometrial cancer cases.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.