C57BL/6 小鼠胃肠道啮齿动物柠檬杆菌定植与微生物群组成之间的可能联系。

IF 1.9 4区医学 Q4 IMMUNOLOGY

Microbiology and Immunology Pub Date : 2024-04-21 DOI:10.1111/1348-0421.13128

Tsuyoshi Miki, Takeshi Haneda, Nobuhiko Okada, Masahiro Ito

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引用次数: 0

摘要

宿主的微生物群通过直接和间接的保护作用赋予宿主定植抗性，从而保护宿主免受肠道感染。在这里，我们确定了肠道微生物群中影响棒状杆菌胃肠道定植的特定成员，棒状杆菌是一种导致结肠隐窝增生的小鼠病原体。可能由于微生物群组成的差异，C57BL/6小鼠的肠道鼠杆菌定植水平在不同饲养设施中有所不同。对微生物群的综合分析表明，微生物群的特定成员可能会影响鼠疫杆菌的肠道定植，从而提供了两者之间的潜在联系。

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Possible link between colonization of the gastrointestinal tract by Citrobacter rodentium in C57BL/6 mice and microbiota composition

Colonization resistance, conferred by the host's microbiota through both direct and indirect protective actions, serves to protect the host from enteric infections. Here, we identified the specific members of the gut microbiota that impact gastrointestinal colonization by Citrobacter rodentium, a murine pathogen causing colonic crypt hyperplasia. The gut colonization levels of C. rodentium in C57BL/6 mice varied among breeding facilities, probably due to differences in microbiota composition. A comprehensive analysis of the microbiota revealed that specific members of the microbiota may influence gut colonization by C. rodentium, thus providing a potential link between the two.

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来源期刊

Microbiology and Immunology 医学-免疫学

CiteScore

5.20

自引率

3.80%

发文量

审稿时长

1 months

期刊介绍： Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.