尼古丁通过抑制 NLRP3 和改变肠道微生物群来改善 DSS 诱导的结肠炎。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI:10.1080/10286020.2024.2331773

Yi-Xiang Zhang , Xiao-Qian Chi , Meng Li , Wei Zhang , Ying Guan , Lian-Qiu Wu

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引用次数: 0

摘要

溃疡性结肠炎（UC）是一种影响直肠和结肠的慢性复发性炎症性疾病。大量流行病学研究发现，吸烟是溃疡性结肠炎的一个保护因素。肠道微生物群失调和炎症因子的释放是与 UC 相关的公认特征。因此，我们观察到尼古丁具有改善 UC 小鼠结肠炎症状的潜力。此外，尼古丁还能促进有益细菌的生长，同时抑制有害细菌，从而对结肠微生物群失调产生调节作用。体内和体外综合研究表明，尼古丁主要会阻碍 NLRP3 的组装，进而抑制下游 IL-1β 的分泌。

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Nicotine improves DSS-induced colitis by inhibiting NLRP3 and altering gut microbiota

Ulcerative colitis (UC) is a chronic recurrent inflammatory disease affecting the rectum and colon. Numerous epidemiological studies have identified smoking as a protective factor for UC. Dysbiosis of intestinal microbiota and release of inflammatory factors are well-established characteristics associated with UC. Therefore, we have observed that nicotine exhibits the potential to ameliorate colitis symptoms in UC mice. Additionally, it exerts a regulatory effect on colonic microbiota dysbiosis by promoting the growth of beneficial bacteria while suppressing harmful bacteria. Combined in vivo and in vitro investigations demonstrate that nicotine primarily impedes the assembly of NLRP3, subsequently inhibiting downstream IL-1β secretion.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.