Jinlong Chang , Miaomiao Han , Yunkai Wang , Li Wang , Fei Lin , Qianfang Jia , Jiawei Xu , Wenhao Yang , Guo-an Zhao , Wu Ren , Zhen Jin
{"title":"基于氧化铁-氢氧化物的多功能纳米棒用于清除硫化氢并辅助结肠癌的协同光热化疗","authors":"Jinlong Chang , Miaomiao Han , Yunkai Wang , Li Wang , Fei Lin , Qianfang Jia , Jiawei Xu , Wenhao Yang , Guo-an Zhao , Wu Ren , Zhen Jin","doi":"10.1016/j.jsamd.2024.100721","DOIUrl":null,"url":null,"abstract":"<div><p>The tumor microenvironment responsive multifunctional nanoplatforms with integrated diagnosis and therapy have recently received great attention in anti-cancer treatment. In this study, we developed biocompatible iron oxide-hydroxide-based nanorods (DOX-FPT NRs) for MR imaging and H<sub>2</sub>S scavenging assisted synergistic photothermal-chemotherapy of colon cancer, which is fabricated by modifying polydopamine (PDA) and transferrin (Tf) on the surface of iron oxide hydroxide (FeOOH) nanorods. The prepared DOX-FPT NRs could precisely target the colon cancer cells through transferrin ligand-receptor-mediated targeting and effectively scavenge endogenous H<sub>2</sub>S to prohibit the growth of colon cancer. Meanwhile, the considerable drug loading capability and outstanding photothermal conversion efficiency are permitted by the PDA shell modification. In addition, the H<sub>2</sub>S scavenging assisted photothermal-chemotherapy showed an excellent therapeutic effect on CT26 cells via <em>in vitro</em> cell test. Therefore, the prepared DOX-PFT NRs will be a promising nanoplatform to enhance the therapeutic effect of colon cancer through the treatment strategy of H<sub>2</sub>S scavenging-assisted synergistic photothermal chemotherapy.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7000,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000522/pdfft?md5=38ac5fcbab0af107a2b4a8898ba8a375&pid=1-s2.0-S2468217924000522-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Multifunctional iron oxide‐hydroxide based nanorods for hydrogen sulfide scavenging assisted synergistic photothermal-chemotherapy of colon cancer\",\"authors\":\"Jinlong Chang , Miaomiao Han , Yunkai Wang , Li Wang , Fei Lin , Qianfang Jia , Jiawei Xu , Wenhao Yang , Guo-an Zhao , Wu Ren , Zhen Jin\",\"doi\":\"10.1016/j.jsamd.2024.100721\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The tumor microenvironment responsive multifunctional nanoplatforms with integrated diagnosis and therapy have recently received great attention in anti-cancer treatment. In this study, we developed biocompatible iron oxide-hydroxide-based nanorods (DOX-FPT NRs) for MR imaging and H<sub>2</sub>S scavenging assisted synergistic photothermal-chemotherapy of colon cancer, which is fabricated by modifying polydopamine (PDA) and transferrin (Tf) on the surface of iron oxide hydroxide (FeOOH) nanorods. The prepared DOX-FPT NRs could precisely target the colon cancer cells through transferrin ligand-receptor-mediated targeting and effectively scavenge endogenous H<sub>2</sub>S to prohibit the growth of colon cancer. Meanwhile, the considerable drug loading capability and outstanding photothermal conversion efficiency are permitted by the PDA shell modification. In addition, the H<sub>2</sub>S scavenging assisted photothermal-chemotherapy showed an excellent therapeutic effect on CT26 cells via <em>in vitro</em> cell test. 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Multifunctional iron oxide‐hydroxide based nanorods for hydrogen sulfide scavenging assisted synergistic photothermal-chemotherapy of colon cancer
The tumor microenvironment responsive multifunctional nanoplatforms with integrated diagnosis and therapy have recently received great attention in anti-cancer treatment. In this study, we developed biocompatible iron oxide-hydroxide-based nanorods (DOX-FPT NRs) for MR imaging and H2S scavenging assisted synergistic photothermal-chemotherapy of colon cancer, which is fabricated by modifying polydopamine (PDA) and transferrin (Tf) on the surface of iron oxide hydroxide (FeOOH) nanorods. The prepared DOX-FPT NRs could precisely target the colon cancer cells through transferrin ligand-receptor-mediated targeting and effectively scavenge endogenous H2S to prohibit the growth of colon cancer. Meanwhile, the considerable drug loading capability and outstanding photothermal conversion efficiency are permitted by the PDA shell modification. In addition, the H2S scavenging assisted photothermal-chemotherapy showed an excellent therapeutic effect on CT26 cells via in vitro cell test. Therefore, the prepared DOX-PFT NRs will be a promising nanoplatform to enhance the therapeutic effect of colon cancer through the treatment strategy of H2S scavenging-assisted synergistic photothermal chemotherapy.
期刊介绍：
In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research.
Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science.
With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.
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