联合使用 ribociclib 和 PARP1 抑制剂对乳腺癌细胞动力学的影响

IF 2.5 4区医学 Q3 ONCOLOGY

Oncology Letters Pub Date : 2024-04-03 DOI:10.3892/ol.2024.14376

Ercan Pulat, Mehmet R Topçul

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引用次数: 0

摘要

本研究评估了 Valamor（VLM）（含有活性成分 ribociclib）和 DPQ（聚（ADP-核糖）聚合酶 1 抑制剂）单独或联合使用对 MCF-7 和 MDA-MB-231 乳腺癌细胞株的体外抗增殖和抗癌作用。VLM 的浓度为 40、80 和 160 微克/毫升，DPQ 的浓度为 3、6 和 9 微克/毫升。测定了细胞增殖率、实时细胞分析系统获得的细胞指数、有丝分裂活性、溴脱氧尿苷细胞增殖和 Caspase 活性参数。总之，从细胞动力学参数得出的结果表明，VLM 和 DPQ 的组合对乳腺癌细胞具有抗癌和抗增殖作用。

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Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer.

In the present study, antiproliferative and anticancer effects of Valamor (VLM), which contains the active component ribociclib, and DPQ, a poly(ADP-ribose) polymerase 1 inhibitor, alone and in combination were evaluated in the MCF-7 and MDA-MB-231 breast cancer cell lines in vitro. VLM was applied at concentrations of 40, 80 and 160 µg/ml, and DPQ was used at concentrations of 3, 6 and 9 µg/ml. The proliferation rate, cell index obtained from the real-time cell analysis system, mitosis activity, bromodeoxyuridine cell proliferation and caspase activity parameters were determined. In conclusion, the results obtained from cell kinetics parameters demonstrated the anticancer and antiproliferative effects of the combination of VLM and DPQ on breast cancer cells.

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来源期刊

Oncology Letters ONCOLOGY-

CiteScore

5.70

自引率

0.00%

发文量

412

审稿时长

2.0 months

期刊介绍： Oncology Letters is a monthly, peer-reviewed journal, available in print and online, that focuses on all aspects of clinical oncology, as well as in vitro and in vivo experimental model systems relevant to the mechanisms of disease. The principal aim of Oncology Letters is to provide the prompt publication of original studies of high quality that pertain to clinical oncology, chemotherapy, oncogenes, carcinogenesis, metastasis, epidemiology and viral oncology in the form of original research, reviews and case reports.