Marco G. Hermann , Nils Schröter , Alexander Rau , Marco Reisert , Nadja Jarc , Michel Rijntjes , Jonas A. Hosp , Peter C. Reinacher , Wolfgang H. Jost , Horst Urbach , Cornelius Weiller , Volker A. Coenen , Bastian E.A. Sajonz
{"title":"帕金森病患者接受脑深部刺激后运动能力的改善与黑质和丘脑下核微结构完整性的关系","authors":"Marco G. Hermann , Nils Schröter , Alexander Rau , Marco Reisert , Nadja Jarc , Michel Rijntjes , Jonas A. Hosp , Peter C. Reinacher , Wolfgang H. Jost , Horst Urbach , Cornelius Weiller , Volker A. Coenen , Bastian E.A. Sajonz","doi":"10.1016/j.nicl.2024.103607","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Nigrostriatal microstructural integrity has been suggested as a biomarker for levodopa response in Parkinson’s disease (PD), which is a strong predictor for motor response to deep brain stimulation (DBS) of the subthalamic nucleus (STN). This study aimed to explore the impact of microstructural integrity of the substantia nigra (SN), STN, and putamen on motor response to STN-DBS using diffusion microstructure imaging.</p></div><div><h3>Methods</h3><p>Data was collected from 23 PD patients (mean age 63 ± 7, 6 females) who underwent STN-DBS, had preoperative 3 T diffusion magnetic resonance imaging including multishell diffusion-weighted MRI with b-values of 1000 and 2000 s/mm<sup>2</sup> and records of motor improvement available.</p></div><div><h3>Results</h3><p>The association between a poorer DBS-response and increased free interstitial fluid showed notable effect sizes (rho > |0.4|) in SN and STN, but not in putamen. However, this did not reach significance after Bonferroni correction and controlling for sex and age.</p></div><div><h3>Conclusion</h3><p>Microstructural integrity of SN and STN are potential biomarkers for the prediction of therapy efficacy following STN-DBS, but further studies are required to confirm these associations.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000469/pdfft?md5=dda85fff005551ad56bc475827a98f7a&pid=1-s2.0-S2213158224000469-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The connection of motor improvement after deep brain stimulation in Parkinson’s disease and microstructural integrity of the substantia nigra and subthalamic nucleus\",\"authors\":\"Marco G. 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This study aimed to explore the impact of microstructural integrity of the substantia nigra (SN), STN, and putamen on motor response to STN-DBS using diffusion microstructure imaging.</p></div><div><h3>Methods</h3><p>Data was collected from 23 PD patients (mean age 63 ± 7, 6 females) who underwent STN-DBS, had preoperative 3 T diffusion magnetic resonance imaging including multishell diffusion-weighted MRI with b-values of 1000 and 2000 s/mm<sup>2</sup> and records of motor improvement available.</p></div><div><h3>Results</h3><p>The association between a poorer DBS-response and increased free interstitial fluid showed notable effect sizes (rho > |0.4|) in SN and STN, but not in putamen. 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The connection of motor improvement after deep brain stimulation in Parkinson’s disease and microstructural integrity of the substantia nigra and subthalamic nucleus
Background
Nigrostriatal microstructural integrity has been suggested as a biomarker for levodopa response in Parkinson’s disease (PD), which is a strong predictor for motor response to deep brain stimulation (DBS) of the subthalamic nucleus (STN). This study aimed to explore the impact of microstructural integrity of the substantia nigra (SN), STN, and putamen on motor response to STN-DBS using diffusion microstructure imaging.
Methods
Data was collected from 23 PD patients (mean age 63 ± 7, 6 females) who underwent STN-DBS, had preoperative 3 T diffusion magnetic resonance imaging including multishell diffusion-weighted MRI with b-values of 1000 and 2000 s/mm2 and records of motor improvement available.
Results
The association between a poorer DBS-response and increased free interstitial fluid showed notable effect sizes (rho > |0.4|) in SN and STN, but not in putamen. However, this did not reach significance after Bonferroni correction and controlling for sex and age.
Conclusion
Microstructural integrity of SN and STN are potential biomarkers for the prediction of therapy efficacy following STN-DBS, but further studies are required to confirm these associations.
期刊介绍：
NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging.
The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.
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