巨噬细胞龛位印记是巨噬细胞特性和功能的决定因素

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology Pub Date : 2024-04-20 DOI:10.1016/j.cellimm.2024.104825

Malgorzata Kloc , Marta Halasa , Rafik M. Ghobrial

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引用次数: 0

摘要

巨噬细胞龛是器官或组织内的解剖位置，由各种细胞、细胞间质和细胞外基质、转录因子和信号分子组成，它们相互作用，影响巨噬细胞的自我维持、表型和行为。巨噬细胞龛除了为巨噬细胞提供物理支持外，还对驻留和浸润的单核细胞和巨噬细胞施加组织和器官特异性特征。在这篇综述中，我们将举例说明巨噬细胞龛以及巨噬细胞与周围细胞之间的交流模式。我们还描述了巨噬细胞如何违背其免疫防御特性，为病原体和癌细胞创造一个适宜的龛位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Macrophage niche imprinting as a determinant of macrophage identity and function

Macrophage niches are the anatomical locations within organs or tissues consisting of various cells, intercellular and extracellular matrix, transcription factors, and signaling molecules that interact to influence macrophage self-maintenance, phenotype, and behavior. The niche, besides physically supporting macrophages, imposes a tissue- and organ-specific identity on the residing and infiltrating monocytes and macrophages. In this review, we give examples of macrophage niches and the modes of communication between macrophages and surrounding cells. We also describe how macrophages, acting against their immune defensive nature, can create a hospitable niche for pathogens and cancer cells.

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来源期刊

Cellular immunology 生物-免疫学

CiteScore

8.20

自引率

2.30%

发文量

102

审稿时长

30 days

期刊介绍： Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.