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引用次数: 0
摘要
免疫疗法是一种前景广阔的长效肿瘤治疗方法，但它面临着肿瘤复杂代谢的挑战。为了优化免疫疗法，必须进一步研究调控肿瘤代谢和免疫反应的关键蛋白。STAT3 在调节肿瘤动态代谢以及通过对各种细胞因子和生长因子的反应影响免疫细胞功能方面发挥着关键作用，可作为免疫疗法的潜在靶点。本综述将重点探讨 STAT3 与肿瘤代谢（包括葡萄糖、脂质和氨基酸代谢）之间的相互影响，以及 STAT3 对 T 细胞、肿瘤相关巨噬细胞（TAMs）和髓源抑制细胞（MDSCs）等免疫细胞的分化和功能的影响，并揭示潜在的治疗策略。
The essential link: How STAT3 connects tumor metabolism to immunity
Immunotherapy is a promising and long-lasting tumor treatment method, but it is challenged by the complex metabolism of tumors. To optimize immunotherapy, it is essential to further investigate the key proteins that regulate tumor metabolism and immune response. STAT3 plays a crucial role in regulating tumor dynamic metabolism and affecting immune cell function by responding to various cytokines and growth factors, which can be used as a potential target for immunotherapy. This review focuses on the crosstalk between STAT3 and tumor metabolism (including glucose, lipid, and amino acid metabolism) and its impact on the differentiation and function of immune cells such as T cells, tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs), and reveals potential treatment strategies.
期刊介绍：
BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.
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