Dan Lin, Cheryl L. Thompson, Alaina Demalis, Rebecca Derbes, Laila Al-Shaar, Emma S. Spielfogel, Kathleen M. Sturgeon
{"title":"诊断前休闲体育活动与乳腺癌复发风险之间的关系：加州教师研究","authors":"Dan Lin, Cheryl L. Thompson, Alaina Demalis, Rebecca Derbes, Laila Al-Shaar, Emma S. Spielfogel, Kathleen M. Sturgeon","doi":"10.1007/s10552-024-01870-8","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Studies have reported inverse associations of pre-diagnosis recreational physical activity (RPA) level with all-cause and breast cancer (BCa)-specific mortality among BCa patients. However, the association between pre-diagnosis RPA level and BCa recurrence is unclear. We investigated the association between pre-diagnosis RPA level and risk of BCa recurrence in the California Teachers Study (CTS).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Stage I–IIIb BCa survivors (<i>n</i> = 6,479) were followed with median of 7.4 years, and 474 BCa recurrence cases were identified. Long-term (from high school to age at baseline questionnaire, or, age 55 years, whichever was younger) and baseline (past 3 years reported at baseline questionnaire) pre-diagnosis RPA levels were converted to metabolic equivalent of task-hours per week (MET-hrs/wk). Multivariable Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of BCa recurrence overall and by estrogen receptor (ER)/progesterone receptor (PR) status.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Long-term RPA was not associated with BCa recurrence risk (<i>p</i><sub>trend</sub> = 0.99). The inverse association between baseline pre-diagnosis RPA level and BCa recurrence risk was marginally significant (≥26.0 vs. <3.4 MET-hrs/wk: HR = 0.79, 95% CI = 0.60–1.03; <i>p</i><sub>trend</sub> = 0.07). However, the association became non-significant after adjusting for post-diagnosis RPA (<i>p</i><sub>trend</sub> = 0.65). An inverse association between baseline pre-diagnosis RPA level and BCa recurrence risk was observed in ER−PR− cases (≥26.0 vs. <3.4 MET-hrs/wk: HR = 0.31, 95% CI = 0.13–0.72; <i>p</i><sub>trend</sub> = 0.04), but not in ER+ or PR+ cases (<i>p</i><sub>trend</sub> = 0.97).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Our data indicates that the benefit of baseline RPA on BCa recurrence may differ by tumor characteristics. This information may be particularly important for populations at higher risk of ER−PR− BCa.</p>","PeriodicalId":9432,"journal":{"name":"Cancer Causes & Control","volume":"56 1","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between pre-diagnosis recreational physical activity and risk of breast cancer recurrence: the California Teachers Study\",\"authors\":\"Dan Lin, Cheryl L. Thompson, Alaina Demalis, Rebecca Derbes, Laila Al-Shaar, Emma S. Spielfogel, Kathleen M. Sturgeon\",\"doi\":\"10.1007/s10552-024-01870-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Purpose</h3><p>Studies have reported inverse associations of pre-diagnosis recreational physical activity (RPA) level with all-cause and breast cancer (BCa)-specific mortality among BCa patients. However, the association between pre-diagnosis RPA level and BCa recurrence is unclear. We investigated the association between pre-diagnosis RPA level and risk of BCa recurrence in the California Teachers Study (CTS).</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>Stage I–IIIb BCa survivors (<i>n</i> = 6,479) were followed with median of 7.4 years, and 474 BCa recurrence cases were identified. Long-term (from high school to age at baseline questionnaire, or, age 55 years, whichever was younger) and baseline (past 3 years reported at baseline questionnaire) pre-diagnosis RPA levels were converted to metabolic equivalent of task-hours per week (MET-hrs/wk). Multivariable Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of BCa recurrence overall and by estrogen receptor (ER)/progesterone receptor (PR) status.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>Long-term RPA was not associated with BCa recurrence risk (<i>p</i><sub>trend</sub> = 0.99). The inverse association between baseline pre-diagnosis RPA level and BCa recurrence risk was marginally significant (≥26.0 vs. <3.4 MET-hrs/wk: HR = 0.79, 95% CI = 0.60–1.03; <i>p</i><sub>trend</sub> = 0.07). However, the association became non-significant after adjusting for post-diagnosis RPA (<i>p</i><sub>trend</sub> = 0.65). An inverse association between baseline pre-diagnosis RPA level and BCa recurrence risk was observed in ER−PR− cases (≥26.0 vs. <3.4 MET-hrs/wk: HR = 0.31, 95% CI = 0.13–0.72; <i>p</i><sub>trend</sub> = 0.04), but not in ER+ or PR+ cases (<i>p</i><sub>trend</sub> = 0.97).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions</h3><p>Our data indicates that the benefit of baseline RPA on BCa recurrence may differ by tumor characteristics. 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Association between pre-diagnosis recreational physical activity and risk of breast cancer recurrence: the California Teachers Study
Purpose
Studies have reported inverse associations of pre-diagnosis recreational physical activity (RPA) level with all-cause and breast cancer (BCa)-specific mortality among BCa patients. However, the association between pre-diagnosis RPA level and BCa recurrence is unclear. We investigated the association between pre-diagnosis RPA level and risk of BCa recurrence in the California Teachers Study (CTS).
Methods
Stage I–IIIb BCa survivors (n = 6,479) were followed with median of 7.4 years, and 474 BCa recurrence cases were identified. Long-term (from high school to age at baseline questionnaire, or, age 55 years, whichever was younger) and baseline (past 3 years reported at baseline questionnaire) pre-diagnosis RPA levels were converted to metabolic equivalent of task-hours per week (MET-hrs/wk). Multivariable Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of BCa recurrence overall and by estrogen receptor (ER)/progesterone receptor (PR) status.
Results
Long-term RPA was not associated with BCa recurrence risk (ptrend = 0.99). The inverse association between baseline pre-diagnosis RPA level and BCa recurrence risk was marginally significant (≥26.0 vs. <3.4 MET-hrs/wk: HR = 0.79, 95% CI = 0.60–1.03; ptrend = 0.07). However, the association became non-significant after adjusting for post-diagnosis RPA (ptrend = 0.65). An inverse association between baseline pre-diagnosis RPA level and BCa recurrence risk was observed in ER−PR− cases (≥26.0 vs. <3.4 MET-hrs/wk: HR = 0.31, 95% CI = 0.13–0.72; ptrend = 0.04), but not in ER+ or PR+ cases (ptrend = 0.97).
Conclusions
Our data indicates that the benefit of baseline RPA on BCa recurrence may differ by tumor characteristics. This information may be particularly important for populations at higher risk of ER−PR− BCa.
期刊介绍：
Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach.
The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues.
The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts.
Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.
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