外部情绪刺激下的视觉事件相关电位是轻度认知障碍的早期信号

IF 4.3 Q2 BUSINESS
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引用次数: 0

摘要

摘要 背景 阿尔茨海默病(Alzheimer's disease,AD)是一种神经退行性疾病,以进行性认知功能衰退为特征,表现为严重的记忆力、注意力、情绪处理和日常活动障碍,导致严重的残疾和社会负担。轻度认知功能障碍(MCI)是介于正常衰老和老年痴呆症之间的前驱和过渡阶段,对它的研究是诊断和延缓老年痴呆症进展的关键。迄今为止,相关研究已取得了许多成果,但对 MCI 和 AD 在不同外部情绪刺激下的注意机制仍未进行深入探讨。 目的 进一步探讨 MCI 和 AD 患者在不同外部情绪刺激下的注意机制。 设计/设置/参与者/测量 我们对 51 名健康志愿者(对照组,男性 24 人,女性 27 人)、52 名 MCI 患者(男性 19 人,女性 33 人)和 47 名 AD 患者(男性 15 人,女性 32 人)进行了三种外部情绪刺激下的视觉奇异事件相关电位(ERPs)测试:其中,我们观察了 N1、P2、N2 和 P3 成分以及与三组显著 ERP 差异相对应的异常皮层激活。 结果 在所有三种外部情绪下,与对照组和 MCI 相比,AD 患者的 N2 和 P3 潜伏期明显延长。此外,与对照组相比,MCI 患者在 "快乐 "情绪下的 P3 潜伏期明显延迟。同时,与对照组和 MCI 相比,AD 患者在 "快乐 "和 "悲伤 "状态下的 P3 振幅分别明显下降。在N2时间窗中,与对照组相比,在中性情绪下,AD患者右颞上回的激活明显减弱;与对照组相比,在快乐情绪下,MCI患者右额下回的激活明显减弱。在 "悲伤 "状态下,与 MCI 相比,AD 患者右额上回的激活明显减少。在 P3 时间窗中,与 MCI 相比,AD 患者在 "快乐 "和 "悲伤 "时,右侧纺锤回和右侧枕中回的激活明显减弱。 结论 我们的研究结果表明,MCI 和 AD 患者在外部情绪刺激下均存在视觉注意缺陷,突出了幸福感在早期检测 MCI 中的作用,其中 P3 潜伏期和 N2 时间窗期间右额叶下回的低激活可作为早期征兆。本研究进一步揭示了 MCI 和 AD 患者的注意机制,并指出了情绪处理在认知功能障碍早期检测中的价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Visual Event-Related Potentials under External Emotional Stimuli as Early Signs for Mild Cognitive Impairment

Abstract

Background

Alzheimer’s disease (AD) is a neurodegenerative disorder featured by progressive cognitive decline, which manifests in severe impairment of memory, attention, emotional processing and daily activities, leading to significant disability and social burden. Investigation on Mild Cognitive Impairment (MCI), the prodromal and transitional stage between normal aging and AD, serves as a key in diagnosing and slowing down the progression of AD. Numerous effects have been made up to date, however, the attentional mechanisms under different external emotion stimuli in MCI and AD are still unexplored in deep.

Objective

To further explore the attentional mechanisms under different external emotion stimuli in both MCI and AD patients.

Design/Setting/Participants/Measurements

In 51 healthy volunteers (Controls, 24 males and 27 females), 52 MCI (19 males and 33 females), and 47 AD (15 males and 32 females) patients, we administered the visual oddball event-related potentials (ERPs) under three types of external emotional stimuli: Neutral, Happiness and Sadness, in which the components N1, P2, N2 and P3 as well as the abnormal cortical activations corresponding to the significant ERP differences in the three groups were observed.

Results

Under all three external emotions, in AD patients, N2 and P3 latencies were significantly prolonged compared to both Controls and MCI. In addition, under Happiness, in MCI, P3 latencies were significantly delayed compared to Controls. Meanwhile, under both Happiness and Sadness, in AD patients, P3 amplitudes were significantly decreased compared to Controls and MCI, respectively. During N2 time window, under Neutral emotion, significant hypoactivation in the right superior temporal gyrus was found in AD patients compared to Controls, and under Happiness, the activation of the right inferior frontal gyrus was significantly attenuated in MCI compared to Controls. Under Sadness, in AD patients, the activation of the right superior frontal gyrus was significantly decreased compared to MCI. During P3 time window, under both Happiness and Sadness, when AD patients compared to MCI, the significantly attenuated activations were located in the right fusiform gyrus and the right middle occipital gyrus, respectively.

Conclusion

Our results demonstrated visual attentional deficits under external emotional stimuli in both MCI and AD patients, highlighting the function of Happiness for early detecting MCI, in which the P3 latency and the hypoactivation of right inferior frontal gyrus during N2 time window can be early signs. The current study sheds further light of attentional mechanisms in MCI and AD patients, and indicates the value of emotional processing in the early detection of cognitive dysfunction.

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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
发文量
0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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