滑石中发现的裂解片段的间皮瘤致病力综述

IF 1.7 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Toxicology and Industrial Health Pub Date : 2024-04-15 DOI:10.1177/07482337241246924

E Miller, EM Beckett, D Cheatham, CE Comerford, RC Lewis, C Krevanko, N Mandava, JS Pierce

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引用次数: 0

摘要

人们早已认识到，透闪石和直闪石的裂隙碎片等闪石矿物可能存在于某些滑石矿床中。我们回顾了影响裂解碎片致间皮瘤效力的因素的科学现状，重点是那些可能同时存在于滑石沉积物中的因素，包括尺寸和结构特征、动物毒理学以及接触滑石相关裂解碎片的研究最充分的人群。根据我们的审查，多种科学证据表明，吸入与滑石粉相关的裂解碎片不会造成间皮瘤危害。

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A review of the mesotheliogenic potency of cleavage fragments found in talc

It has long been recognized that amphibole minerals, such as cleavage fragments of tremolite and anthophyllite, may exist in some talc deposits. We reviewed the current state of the science regarding the factors influencing mesotheliogenic potency of cleavage fragments, with emphasis on those that may co-occur in talc deposits, including dimensional and structural characteristics, animal toxicology, and the most well-studied cohort exposed to talc-associated cleavage fragments. Based on our review, multiple lines of scientific evidence demonstrate that inhaled cleavage fragments associated with talc do not pose a mesothelioma hazard.

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来源期刊

Toxicology and Industrial Health 医学-毒理学

CiteScore

3.50

自引率

5.30%

发文量

审稿时长

4 months

期刊介绍： Toxicology & Industrial Health is a journal dedicated to reporting results of basic and applied toxicological research with direct application to industrial/occupational health. Such research includes the fields of genetic and cellular toxicology and risk assessment associated with hazardous wastes and groundwater.