膝关节假体植入失败的患者也会出现轻度无菌性淋巴细胞为主的血管炎相关病变（ALVAL）型反应。

IF 4.7 2区医学 Q2 CELL & TISSUE ENGINEERING

Bone & Joint Research Pub Date : 2024-04-04 DOI:10.1302/2046-3758.134.bjr-2023-0255.r1

Anni Rajamäki, Lari Lehtovirta, Mika Niemeläinen, Aleksi Reito, Jyrki Parkkinen, Sirpa Peräniemi, Jouko Vepsäläinen, Antti Eskelinen

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引用次数: 0

摘要

从金属髋关节假体（MoM-THA）上脱落的金属颗粒已被证明会引起炎症和组织破坏。为了进一步探讨这一问题，我们对接受翻修膝关节置换术的患者假体周围组织的组织病理学（无菌性淋巴细胞为主的血管炎相关病变（ALVAL）评分）和金属浓度进行了调查。我们还旨在研究累积的金属碎片是否与滑膜中的 ALVAL 型反应有关。

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Mild aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL)-type reactions also present in patients with failed knee prostheses.

Metal particles detached from metal-on-metal hip prostheses (MoM-THA) have been shown to cause inflammation and destruction of tissues. To further explore this, we investigated the histopathology (aseptic lymphocyte-dominated vasculitis-associated lesions (ALVAL) score) and metal concentrations of the periprosthetic tissues obtained from patients who underwent revision knee arthroplasty. We also aimed to investigate whether accumulated metal debris was associated with ALVAL-type reactions in the synovium.

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来源期刊

Bone & Joint Research CELL & TISSUE ENGINEERING-ORTHOPEDICS

CiteScore

7.40

自引率

23.90%

发文量

156

审稿时长

12 weeks

期刊介绍： The gold open access journal for the musculoskeletal sciences. Included in PubMed and available in PubMed Central.