{"title":"利用高效液相色谱法和分光光度法同时测定抗菌液中的洗必泰、对氯苯胺、三氯生、邻苯二甲酸二丁酯和离子醇","authors":"A. V. Pirogov, S. M. Staroverov","doi":"10.3103/S0027131424010073","DOIUrl":null,"url":null,"abstract":"<p>This article studies the development of a simple chromatographic method for the simultaneous determination of well-known antiseptics—chlorhexidine and triclosan—in new-generation antiseptic liquids. The dependencies of the retention times of chlorhexidine and triclosan on the concentration of acetonitrile in the mobile phase (30 to 60%) and pH (in a range of 3–8 units) for Luna C18, Nucleosil CN, and Diasfer C4 sorbents are studied. Ideal separation of chlorhexidine, <i>p</i>-chloroaniline (the most toxic decomposition product of chlorhexidine), dibutyl phthalate (as a component of cosmetic alcohol), triclosan, and ionol (butylhydroxytoluene (BHT) and E321—an antioxidant agent) during 20 min in the gradient elution mode on a column with a domestic Diasfer C4 sorbent is demonstrated.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 1","pages":"41 - 49"},"PeriodicalIF":0.7000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Simultaneous Determination of Chlorhexidine, p-Chloroaniline, Triclosan, Dibutyl Phthalate, and Ionol in an Antibacterial Liquid by HPLC with Spectrophotometric Detection\",\"authors\":\"A. V. Pirogov, S. M. Staroverov\",\"doi\":\"10.3103/S0027131424010073\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This article studies the development of a simple chromatographic method for the simultaneous determination of well-known antiseptics—chlorhexidine and triclosan—in new-generation antiseptic liquids. The dependencies of the retention times of chlorhexidine and triclosan on the concentration of acetonitrile in the mobile phase (30 to 60%) and pH (in a range of 3–8 units) for Luna C18, Nucleosil CN, and Diasfer C4 sorbents are studied. Ideal separation of chlorhexidine, <i>p</i>-chloroaniline (the most toxic decomposition product of chlorhexidine), dibutyl phthalate (as a component of cosmetic alcohol), triclosan, and ionol (butylhydroxytoluene (BHT) and E321—an antioxidant agent) during 20 min in the gradient elution mode on a column with a domestic Diasfer C4 sorbent is demonstrated.</p>\",\"PeriodicalId\":709,\"journal\":{\"name\":\"Moscow University Chemistry Bulletin\",\"volume\":\"79 1\",\"pages\":\"41 - 49\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Moscow University Chemistry Bulletin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.3103/S0027131424010073\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moscow University Chemistry Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.3103/S0027131424010073","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Simultaneous Determination of Chlorhexidine, p-Chloroaniline, Triclosan, Dibutyl Phthalate, and Ionol in an Antibacterial Liquid by HPLC with Spectrophotometric Detection
This article studies the development of a simple chromatographic method for the simultaneous determination of well-known antiseptics—chlorhexidine and triclosan—in new-generation antiseptic liquids. The dependencies of the retention times of chlorhexidine and triclosan on the concentration of acetonitrile in the mobile phase (30 to 60%) and pH (in a range of 3–8 units) for Luna C18, Nucleosil CN, and Diasfer C4 sorbents are studied. Ideal separation of chlorhexidine, p-chloroaniline (the most toxic decomposition product of chlorhexidine), dibutyl phthalate (as a component of cosmetic alcohol), triclosan, and ionol (butylhydroxytoluene (BHT) and E321—an antioxidant agent) during 20 min in the gradient elution mode on a column with a domestic Diasfer C4 sorbent is demonstrated.
期刊介绍：
Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.
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