新型 1,3,4-恶二唑和苯并[d]咪唑支架作为前景看好的抗菌剂的合成与生物评价研究

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2024-04-02 DOI:10.3103/s0027131424010036

Dinesh. R. Godhani, Anwar. H. Saiyad, Jignasu. P. Mehta, Umang. P. Mehta

{"title":"新型 1,3,4-恶二唑和苯并[d]咪唑支架作为前景看好的抗菌剂的合成与生物评价研究","authors":"Dinesh. R. Godhani, Anwar. H. Saiyad, Jignasu. P. Mehta, Umang. P. Mehta","doi":"10.3103/s0027131424010036","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3>We prepared a novel series of 1,3,4-oxadiazole and benzo[d]imidazolecontaining fi fteen new connections to develop potential antimicrobial agents (9a–9o). The structures of this new series were characterized by various spectral techniques like IR, 1H NMR, 13C NMR, LC–MS, and elemental analysis. Using the Broth Dilution method, the hybrids were examined for antimicrobial activity against a variety of bacterial and fungal strains. Compound 9n (MIC = 50 μg/mL) exhibited good activity against gramnegative E. coli and compound 9m (MIC = 50 μg/mL) showed potent activity against P. aeruginosa. While compounds 9c, 9f, 9g and 9m indicated MIC = 250 μg/mL against C. albicans.","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Biological Evaluation Studies of Novel 1,3,4-Oxadiazole and Benzo[d]imidazole Scaffolds as Promising Antimicrobial Agents\",\"authors\":\"Dinesh. R. Godhani, Anwar. H. Saiyad, Jignasu. P. Mehta, Umang. P. Mehta\",\"doi\":\"10.3103/s0027131424010036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3>We prepared a novel series of 1,3,4-oxadiazole and benzo[d]imidazolecontaining fi fteen new connections to develop potential antimicrobial agents (9a–9o). The structures of this new series were characterized by various spectral techniques like IR, 1H NMR, 13C NMR, LC–MS, and elemental analysis. Using the Broth Dilution method, the hybrids were examined for antimicrobial activity against a variety of bacterial and fungal strains. Compound 9n (MIC = 50 μg/mL) exhibited good activity against gramnegative E. coli and compound 9m (MIC = 50 μg/mL) showed potent activity against P. aeruginosa. While compounds 9c, 9f, 9g and 9m indicated MIC = 250 μg/mL against C. albicans.\",\"PeriodicalId\":709,\"journal\":{\"name\":\"Moscow University Chemistry Bulletin\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Moscow University Chemistry Bulletin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3103/s0027131424010036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moscow University Chemistry Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3103/s0027131424010036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

摘要我们制备了一系列新的含 1,3,4-恶二唑和苯并[d]咪唑的 15 种新连接物，以开发潜在的抗菌剂（9a-9o）。通过红外光谱、1H NMR、13C NMR、LC-MS 和元素分析等各种光谱技术对这一新系列的结构进行了表征。采用肉汤稀释法检测了杂交化合物对多种细菌和真菌菌株的抗菌活性。化合物 9n（MIC = 50 μg/mL）对革兰氏阴性大肠杆菌具有良好的活性，化合物 9m（MIC = 50 μg/mL）对铜绿假单胞菌具有很强的活性。化合物 9c、9f、9g 和 9m 对白僵菌的 MIC = 250 μg/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Synthesis and Biological Evaluation Studies of Novel 1,3,4-Oxadiazole and Benzo[d]imidazole Scaffolds as Promising Antimicrobial Agents

Abstract

We prepared a novel series of 1,3,4-oxadiazole and benzo[d]imidazolecontaining fi fteen new connections to develop potential antimicrobial agents (9a–9o). The structures of this new series were characterized by various spectral techniques like IR, ¹H NMR, ¹³C NMR, LC–MS, and elemental analysis. Using the Broth Dilution method, the hybrids were examined for antimicrobial activity against a variety of bacterial and fungal strains. Compound 9n (MIC = 50 μg/mL) exhibited good activity against gramnegative E. coli and compound 9m (MIC = 50 μg/mL) showed potent activity against P. aeruginosa. While compounds 9c, 9f, 9g and 9m indicated MIC = 250 μg/mL against C. albicans.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.