在脸部和颈部,瘢痕疙瘩的分布与皮肤厚度和与运动相关的僵硬变化有关

IF 3.8 3区 医学 Q2 CELL BIOLOGY
Hoyu Cho, Teruyuki Dohi, Hanae Wakai, Whitney Laurel Quong, Nguyen Doan Tien Linh, Satoshi Usami, Rei Ogawa
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引用次数: 0

摘要

由于瘢痕疙瘩的形成与机械刺激有关,因此瘢痕疙瘩往往发生在高张力部位。迄今为止,还没有专门针对面部和颈部瘢痕疙瘩分布进行详细分析的报道,有关机械因素的文献也很有限。为了弥补这一知识缺陷,我们首先量化了临床上观察到的 113 名患者的面部和颈部瘢痕疙瘩分布情况。随后,我们对无病理瘢痕史的健康志愿者的这些解剖部位的机械因素及其相关变化进行了严格的调查。我们还研究了瘢痕疙瘩选取部位与皮脂腺密集和痤疮易发部位之间的关联。为了评估皮肤的伸展性、厚度和硬度,使用了 VECTRA、超声波和压痕仪。测量了基线皮肤硬度和厚度,以及与面部表情和体位变化相关的这些值的变化幅度。在面部和颈部,瘢痕疙瘩最常见的部位是下颌角(41.3%)和外侧下颌角(20.0%)。这些瘢痕疙瘩发病率较高的区域与皮脂腺较密集的区域没有关联,也与痤疮易发区域没有一致的联系。二项式逻辑回归显示,与体位变化有关的皮肤硬度和厚度变化可显著预测瘢痕疙瘩的分布。与长期机械力(体位变化)相关的皮肤硬度和厚度变化在瘢痕疙瘩高发部位最为明显。这一发现进一步阐明了皮肤拉伸和张力与瘢痕疙瘩发展的关系。作为对面部和颈部皮肤机械力的更详细分析,本研究评估了多种皮肤机械特性的细微差别及其在三维框架中的变化。这些因素对于更好地了解瘢痕疙瘩在面部和颈部的进展和发展可能至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In the face and neck, keloid scar distribution is related to skin thickness and stiffness changes associated with movement
Keloid scars tend to occur in high‐tension sites due to mechanical stimuli that are involved in their development. To date, a detailed analysis of keloid distribution focused specifically on facial and neck areas has not been reported, and limited literature exists as to the related mechanical factors. To rectify this deficiency of knowledge, we first quantified the facial and neck keloid distribution observed clinically in 113 patients. Subsequently, we performed a rigorous investigation into the mechanical factors and their associated changes at these anatomic sites in healthy volunteers without a history of pathologic scarring. The association between keloid‐predilection sites and sebaceous gland‐dense and acne‐prone sites was also examined. To assess skin stretch, thickness and stiffness, VECTRA, ultrasound and indentometer were utilised. Baseline skin stiffness and thickness were measured, as well as the magnitude of change in these values associated with facial expression and postural changes. Within the face and neck, keloids were most common near the mandibular angle (41.3%) and lateral submental (20.0%) regions. These areas of increased keloid incidence were not associated with areas more dense in sebaceous glands, nor linked consistently with acne‐susceptible regions. Binomial logistic regression revealed that changes in skin stiffness and thickness related to postural changes significantly predicted keloid distribution. Skin stiffness and thickness changes related to prolonged mechanical forces (postural changes) are most pronounced at sites of high keloid predilection. This finding further elucidates the means by which skin stretch and tension are related to keloid development. As a more detailed analysis of mechanical forces on facial and neck skin, this study evaluates the nuances of multiple skin‐mechanical properties, and their changes in a three‐dimensional framework. Such factors may be critical to better understanding keloid progression and development in the face and neck.
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来源期刊
Wound Repair and Regeneration
Wound Repair and Regeneration 医学-皮肤病学
CiteScore
5.90
自引率
3.40%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.
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