催乳素受体：基因结构、转录调控、组织特异性和遗传变异的跨物种比较

IF 3.3 4区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Neuroendocrinology Pub Date : 2024-04-08 DOI:10.1111/jne.13385

Carmen M. Banks, Josephine F. Trott, Russell C. Hovey

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引用次数: 0

摘要

催乳素（PRL）的保守和多方面功能是通过其细胞表面受体（PRLR）在一系列组织和生理状态中的不同分布和表达来协调的。因此，PRLR mRNA 和蛋白质在不同器官和细胞类型中的异质性表达支持了一系列 PRL 调节的过程，包括生殖、泌乳、发育和平衡。PRLR 基因内的遗传变异也是影响农业生产和人类病理的几种表型的原因。本综述旨在强调控制不同组织中 PRLR 不同表达的许多因素，以及由于 PRLR 基因变异而在不同物种中存在的各种表型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The prolactin receptor: A cross-species comparison of gene structure, transcriptional regulation, tissue-specificity, and genetic variation

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The prolactin receptor: A cross-species comparison of gene structure, transcriptional regulation, tissue-specificity, and genetic variation

The conserved and multifaceted functions of prolactin (PRL) are coordinated through varied distribution and expression of its cell-surface receptor (PRLR) across a range of tissues and physiological states. The resultant heterogeneous expression of PRLR mRNA and protein across different organs and cell types supports a wide range of PRL-regulated processes including reproduction, lactation, development, and homeostasis. Genetic variation within the PRLR gene also accounts for several phenotypes impacting agricultural production and human pathology. The goal of this review is to highlight the many elements that control differential expression of the PRLR across tissues, and the various phenotypes that exist across species due to variation in the PRLR gene.

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来源期刊

Journal of Neuroendocrinology 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.20%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Journal of Neuroendocrinology provides the principal international focus for the newest ideas in classical neuroendocrinology and its expanding interface with the regulation of behavioural, cognitive, developmental, degenerative and metabolic processes. Through the rapid publication of original manuscripts and provocative review articles, it provides essential reading for basic scientists and clinicians researching in this rapidly expanding field. In determining content, the primary considerations are excellence, relevance and novelty. While Journal of Neuroendocrinology reflects the broad scientific and clinical interests of the BSN membership, the editorial team, led by Professor Julian Mercer, ensures that the journal’s ethos, authorship, content and purpose are those expected of a leading international publication.