POEM 用于治疗非achalasia 痉挛性食道运动障碍

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
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引用次数: 0

摘要

非胆囊炎性食管运动障碍(NAOMD)是一组异质性罕见疾病,包括食管胃交界处流出道梗阻、食管远端痉挛和食管过度收缩。尽管这些疾病的病因、人体测量学和病理生理学特征各不相同,但其临床表现却十分相似,包括吞咽困难和胸痛。这些疾病的治疗仍然是临床医生面临的一项挑战。药物疗法、肉毒杆菌毒素注射、内窥镜扩张术和腹腔镜海勒肌切开术已被采用,但对大多数患者的疗效有限。目前,还没有文献对照研究表明哪种方法是治疗这些疾病的最佳方法。自从口腔内窥镜肌切开术(POEM)被引入临床实践以来,它已成为治疗食道贲门失弛缓症的一种非常有前途的微创有效疗法。然而,由于研究样本量小和短期随访,目前可用的数据受到限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
POEM for non-achalasia spastic oesophageal motility disorders

Non-achalasia oesophageal motility disorders (NAOMD) represent a heterogeneous group of rare diseases, including oesophagogastric junction outflow obstruction, distal oesophageal spasm, and hypercontractile oesophagus. Despite the differing aetiological, manometric and pathophysiological characteristics, these disorders are unified by similar clinical presentation, including dysphagia and chest pain. The management of these disorders remain a challenge for the clinician. Pharmacotherapy, botulinum toxin injection, endoscopic dilation, and laparoscopic Heller myotomy have been employed, with limited efficacy in the majority of patients. Currently, there are no controlled studies in literature that suggest which is the best management of these diseases. Since its introduction in clinical practice, PerOral Endoscopic Myotomy (POEM) has emerged as a very promising, minimally invasive and effective treatment for oesophageal achalasia. No longer after the first uses, POEM has been successfully used also for the management of selected patients with NAOMD, However, currently available data are limited by small study sample sizes and short-term follow-up.

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来源期刊
CiteScore
5.50
自引率
0.00%
发文量
23
审稿时长
69 days
期刊介绍: Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.
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