癌症治疗中的磁热效应、机制和最新进展：综述

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2024-04-12 DOI:10.1177/08853282241244707

Mohammad Jafar Molaei

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引用次数: 0

摘要

热疗是指为达到治疗目的而升高人体某一区域的温度。热疗应用了不同的技术，包括激光、微波、射频、超声波和磁性纳米粒子，其中磁性纳米粒子近年来备受关注。磁性热疗在癌症治疗中的应用旨在借助外部交变磁场，将磁性纳米粒子的热量局部传递给癌细胞，从而提高人体组织的温度，达到杀死癌细胞或阻止其进一步生长的目的。本综述介绍了利用磁性纳米粒子的磁热疗。它包括磁性热疗现象背后的运行机制和磁性。还讨论了不同的合成方法和表面改性，以提高纳米粒子的生物相容性、水溶性和在生理环境中的稳定性。此外，还讨论了关于具有提高局部温度能力的多功能磁性纳米粒子的最新研究。

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Magnetic hyperthermia in cancer therapy, mechanisms, and recent advances: A review

Hyperthermia therapy refers to the elevating of a region in the body for therapeutic purposes. Different techniques have been applied for hyperthermia therapy including laser, microwave, radiofrequency, ultrasonic, and magnetic nanoparticles and the latter have received great attention in recent years. Magnetic hyperthermia in cancer therapy aims to increase the temperature of the body tissue by locally delivering heat from the magnetic nanoparticles to cancer cells with the aid of an external alternating magnetic field to kill the cancerous cells or prevent their further growth. This review introduces magnetic hyperthermia with magnetic nanoparticles. It includes the mechanism of the operation and magnetism behind the magnetic hyperthermia phenomenon. Different synthesis methods and surface modification to enhance the biocompatibility, water solubility, and stability of the nanoparticles in physiological environments have been discussed. Recent research on versatile types of magnetic nanoparticles with their ability to increase the local temperature has been addressed.

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.