穿心莲内酯衍生物的合成与药物应用探索：综述

IF 1.7 3区化学 Q3 CHEMISTRY, ORGANIC

Current Organic Chemistry Pub Date : 2024-04-04 DOI:10.2174/0113852728296785240308054135

Tanzeela Qadir, Shoaib Shaikh, Saadat A. Kanth, Jyotika Singh, Maria Baby, Praveen Kumar Sharma

{"title":"穿心莲内酯衍生物的合成与药物应用探索：综述","authors":"Tanzeela Qadir, Shoaib Shaikh, Saadat A. Kanth, Jyotika Singh, Maria Baby, Praveen Kumar Sharma","doi":"10.2174/0113852728296785240308054135","DOIUrl":null,"url":null,"abstract":": Andrographolide, derived from the plant Andrographis paniculata (AP), exhibits a diverse range of biological activities, encompassing anti-bacterial, anti-tumor, anti-inflammatory, anti-obesity, anti-viral, antifibrotic, hypoglycemic, and immunomodulatory properties. Notably, numerous analogs of andrographolide have been synthesized, incorporating significant chemical structural modifications to enhance bioavailability and druggability. A comprehensive exploration into their molecular and cellular mechanisms of action has also been undertaken, enriching our understanding. The investigation highlights the potential of related terpenoid analogs from Andrographis paniculata, beyond the diterpene lactone andrographolide, to hold promise in disease treatment due to structural similarities and diverse pharmacological effects. This review offers insights into the anticipated synthesis and therapeutic applications of andrographolide derivatives across a spectrum of disorders.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"111 1","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring Synthesis and Medicinal Applications of Andrographolide Derivatives: A Review\",\"authors\":\"Tanzeela Qadir, Shoaib Shaikh, Saadat A. Kanth, Jyotika Singh, Maria Baby, Praveen Kumar Sharma\",\"doi\":\"10.2174/0113852728296785240308054135\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": Andrographolide, derived from the plant Andrographis paniculata (AP), exhibits a diverse range of biological activities, encompassing anti-bacterial, anti-tumor, anti-inflammatory, anti-obesity, anti-viral, antifibrotic, hypoglycemic, and immunomodulatory properties. Notably, numerous analogs of andrographolide have been synthesized, incorporating significant chemical structural modifications to enhance bioavailability and druggability. A comprehensive exploration into their molecular and cellular mechanisms of action has also been undertaken, enriching our understanding. The investigation highlights the potential of related terpenoid analogs from Andrographis paniculata, beyond the diterpene lactone andrographolide, to hold promise in disease treatment due to structural similarities and diverse pharmacological effects. This review offers insights into the anticipated synthesis and therapeutic applications of andrographolide derivatives across a spectrum of disorders.\",\"PeriodicalId\":10926,\"journal\":{\"name\":\"Current Organic Chemistry\",\"volume\":\"111 1\",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2174/0113852728296785240308054135\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0113852728296785240308054135","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

:穿心莲内酯提取自穿心莲（AP），具有多种生物活性，包括抗菌、抗肿瘤、抗炎、抗肥胖、抗病毒、抗纤维化、降血糖和免疫调节特性。值得注意的是，人们合成了许多穿心莲内酯类似物，对其化学结构进行了重大调整，以提高生物利用度和可药用性。此外，还对其分子和细胞作用机制进行了全面探索，丰富了我们的认识。这项研究强调了穿心莲中除二萜内酯穿心莲内酯以外的相关萜类类似物在疾病治疗方面的潜力，这些类似物具有结构相似性和不同的药理作用。本综述深入探讨了穿心莲内酯衍生物在各种疾病中的预期合成和治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Exploring Synthesis and Medicinal Applications of Andrographolide Derivatives: A Review

: Andrographolide, derived from the plant Andrographis paniculata (AP), exhibits a diverse range of biological activities, encompassing anti-bacterial, anti-tumor, anti-inflammatory, anti-obesity, anti-viral, antifibrotic, hypoglycemic, and immunomodulatory properties. Notably, numerous analogs of andrographolide have been synthesized, incorporating significant chemical structural modifications to enhance bioavailability and druggability. A comprehensive exploration into their molecular and cellular mechanisms of action has also been undertaken, enriching our understanding. The investigation highlights the potential of related terpenoid analogs from Andrographis paniculata, beyond the diterpene lactone andrographolide, to hold promise in disease treatment due to structural similarities and diverse pharmacological effects. This review offers insights into the anticipated synthesis and therapeutic applications of andrographolide derivatives across a spectrum of disorders.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Organic Chemistry 化学-有机化学

CiteScore

3.70

自引率

7.70%

发文量

审稿时长

1 months

期刊介绍： Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.