Tanzeela Qadir, Shoaib Shaikh, Saadat A. Kanth, Jyotika Singh, Maria Baby, Praveen Kumar Sharma
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Exploring Synthesis and Medicinal Applications of Andrographolide Derivatives: A Review
: Andrographolide, derived from the plant Andrographis paniculata (AP), exhibits a diverse range of biological activities, encompassing anti-bacterial, anti-tumor, anti-inflammatory, anti-obesity, anti-viral, antifibrotic, hypoglycemic, and immunomodulatory properties. Notably, numerous analogs of andrographolide have been synthesized, incorporating significant chemical structural modifications to enhance bioavailability and druggability. A comprehensive exploration into their molecular and cellular mechanisms of action has also been undertaken, enriching our understanding. The investigation highlights the potential of related terpenoid analogs from Andrographis paniculata, beyond the diterpene lactone andrographolide, to hold promise in disease treatment due to structural similarities and diverse pharmacological effects. This review offers insights into the anticipated synthesis and therapeutic applications of andrographolide derivatives across a spectrum of disorders.
期刊介绍:
Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.