Carla Cellesi , Clara Michelangeli , Gian Maria Rossolini , Franco Giovannoni , Aldo Rossolini
{"title":"在基本三剂免疫计划后6至15年对白喉免疫","authors":"Carla Cellesi , Clara Michelangeli , Gian Maria Rossolini , Franco Giovannoni , Aldo Rossolini","doi":"10.1016/0092-1157(89)90025-5","DOIUrl":null,"url":null,"abstract":"<div><p>The results of a study of the immunity to diphtheria of 283 girls (9–18 years of age) vaccinated at the age of two years with three doses of vaccine, are reported. The rabbit skin test was used to determine the titre of serum diphtheria antitoxin. 55·8% of the subjects were found to be protected (titre ≥ 0·1 IU/ml), 38·9% were only relatively immune (titre ≥ 0·01-< 0·1 IU/ml), and 5·3% were unprotected (titre < 0·01 IU/ml). The antitoxin titres showed a tendency to decrease with time. Even so, 6–15 years after vaccination, the percentages of protected and partially protected subjects were still high (95%).</p></div>","PeriodicalId":75991,"journal":{"name":"Journal of biological standardization","volume":"17 1","pages":"Pages 29-34"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0092-1157(89)90025-5","citationCount":"8","resultStr":"{\"title\":\"Immunity to diphtheria, six to 15 years after a basic three-dose immunization schedule\",\"authors\":\"Carla Cellesi , Clara Michelangeli , Gian Maria Rossolini , Franco Giovannoni , Aldo Rossolini\",\"doi\":\"10.1016/0092-1157(89)90025-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The results of a study of the immunity to diphtheria of 283 girls (9–18 years of age) vaccinated at the age of two years with three doses of vaccine, are reported. The rabbit skin test was used to determine the titre of serum diphtheria antitoxin. 55·8% of the subjects were found to be protected (titre ≥ 0·1 IU/ml), 38·9% were only relatively immune (titre ≥ 0·01-< 0·1 IU/ml), and 5·3% were unprotected (titre < 0·01 IU/ml). The antitoxin titres showed a tendency to decrease with time. Even so, 6–15 years after vaccination, the percentages of protected and partially protected subjects were still high (95%).</p></div>\",\"PeriodicalId\":75991,\"journal\":{\"name\":\"Journal of biological standardization\",\"volume\":\"17 1\",\"pages\":\"Pages 29-34\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0092-1157(89)90025-5\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of biological standardization\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0092115789900255\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biological standardization","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0092115789900255","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immunity to diphtheria, six to 15 years after a basic three-dose immunization schedule
The results of a study of the immunity to diphtheria of 283 girls (9–18 years of age) vaccinated at the age of two years with three doses of vaccine, are reported. The rabbit skin test was used to determine the titre of serum diphtheria antitoxin. 55·8% of the subjects were found to be protected (titre ≥ 0·1 IU/ml), 38·9% were only relatively immune (titre ≥ 0·01-< 0·1 IU/ml), and 5·3% were unprotected (titre < 0·01 IU/ml). The antitoxin titres showed a tendency to decrease with time. Even so, 6–15 years after vaccination, the percentages of protected and partially protected subjects were still high (95%).
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