WHAMM 在肾脏重吸收中发挥作用，并聚合肌动蛋白，促进自噬体膜闭合和货物螯合

IF 3.1 3区生物学 Q3 CELL BIOLOGY

Molecular Biology of the Cell Pub Date : 2024-04-10 DOI:10.1091/mbc.e24-01-0025

Alyssa M Coulter, Valerie Cortés, Corey J Theodore, Rachel E Cianciolo, Ron Korstanje, Kenneth G Campellone

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引用次数: 0

摘要

缺乏肌动蛋白成核因子 WHAMM 的小鼠表现出类似范可尼综合征的肾脏疾病症状。缺乏 WHAMM 的雄性小鼠的肾脏在结构和重吸收功能方面出现异常。WHAMM和Arp2/3复合物对肾脏的营养重吸收和近端肾小管细胞的自噬体重塑非常重要。

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WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration

The tissue-specific functions of mammalian actin nucleation factors are not well understood.
Mice lacking the actin nucleation factor WHAMM show signs of a kidney disease resembling Fanconi Syndrome. Kidneys from WHAMM-deficient male mice display abnormalities in structure and reabsorption function. Cultured proximal tubule cells exhibit defects in autophagosome closure and autophagic cargo sequestration.
WHAMM and the Arp2/3 complex are important for nutrient reabsorption in the kidney and autophagosome remodeling in proximal tubule cells.

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来源期刊

Molecular Biology of the Cell 生物-细胞生物学

CiteScore

6.00

自引率

6.10%

发文量

402

审稿时长

2 months

期刊介绍： MBoC publishes research articles that present conceptual advances of broad interest and significance within all areas of cell, molecular, and developmental biology. We welcome manuscripts that describe advances with applications across topics including but not limited to: cell growth and division; nuclear and cytoskeletal processes; membrane trafficking and autophagy; organelle biology; quantitative cell biology; physical cell biology and mechanobiology; cell signaling; stem cell biology and development; cancer biology; cellular immunology and microbial pathogenesis; cellular neurobiology; prokaryotic cell biology; and cell biology of disease.