裂殖酵母的双稳态有丝分裂开关

IF 3.1 3区生物学 Q3 CELL BIOLOGY

Molecular Biology of the Cell Pub Date : 2024-04-10 DOI:10.1091/mbc.e24-03-0142

Béla Novák, John J. Tyson

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引用次数: 0

摘要

基于他们优雅的实验，Patterson等人（eLife，2021年）认为裂殖酵母的G2/M转换是由双稳态开关控制的，但我们对这一结论提出了质疑。我们建议进行一项决定性实验，以明确区分不可逆/双稳态开关和可逆/超敏感开关。

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The bistable mitotic switch in fission yeast

Based on their elegant experiments, Patterson et al. (eLife, 2021) concluded that the G2/M transition in fission yeast is controlled by a bistable switch, but we question that conclusion.
Using detailed stochastic simulations, we show that the coexisting low and high Cdk1 activity states observed by Patterson et al. can be reproduced by either an irreversible/bistable or a reversible/ultrasensitive switch, and our analysis shows why the experiments of Patterson et al. are inconclusive.
We suggest a decisive experiment to distinguish unequivocally between an irreversible/bistable and a reversible/ultrasensitive switch.

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来源期刊

Molecular Biology of the Cell 生物-细胞生物学

CiteScore

6.00

自引率

6.10%

发文量

402

审稿时长

2 months

期刊介绍： MBoC publishes research articles that present conceptual advances of broad interest and significance within all areas of cell, molecular, and developmental biology. We welcome manuscripts that describe advances with applications across topics including but not limited to: cell growth and division; nuclear and cytoskeletal processes; membrane trafficking and autophagy; organelle biology; quantitative cell biology; physical cell biology and mechanobiology; cell signaling; stem cell biology and development; cancer biology; cellular immunology and microbial pathogenesis; cellular neurobiology; prokaryotic cell biology; and cell biology of disease.