SNX-BAR Paralogs Vps5 和 Vin1 中的 N 端信号引导内体衣壳复合体的形成

IF 3.1 3区生物学 Q3 CELL BIOLOGY

Molecular Biology of the Cell Pub Date : 2024-04-10 DOI:10.1091/mbc.e24-01-0043

Shawn P. Shortill, Mia S. Frier, Michael Davey, Elizabeth Conibear

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引用次数: 0

摘要

我们发现了两种酵母 SNX-BAR（Vps5 和 Vin1）同源物的非结构化 N 端的特征，它们介导了相关 retromer 和 VINE 复合物的特异性形成。

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N-terminal signals in the SNX-BAR paralogs Vps5 and Vin1 guide endosomal coat complex formation

The assembly of BAR domain-containing endosomal coats such as retromer involves BAR-BAR pairing, though recent work suggests that additional structural features contribute to subunit selection
We identified features in the unstructured N-termini of two paralogous yeast SNX-BARs, Vps5 and Vin1, that mediate the specific formation of the related retromer and VINE complexes
Our findings highlight how disordered regions in SNX-BARs help determine the composition of sorting complexes, thereby clarifying mechanisms of modular membrane coat assembly

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来源期刊

Molecular Biology of the Cell 生物-细胞生物学

CiteScore

6.00

自引率

6.10%

发文量

402

审稿时长

2 months

期刊介绍： MBoC publishes research articles that present conceptual advances of broad interest and significance within all areas of cell, molecular, and developmental biology. We welcome manuscripts that describe advances with applications across topics including but not limited to: cell growth and division; nuclear and cytoskeletal processes; membrane trafficking and autophagy; organelle biology; quantitative cell biology; physical cell biology and mechanobiology; cell signaling; stem cell biology and development; cancer biology; cellular immunology and microbial pathogenesis; cellular neurobiology; prokaryotic cell biology; and cell biology of disease.