Shi Rui Seow, Sumaiyah Mat, Amalina Ahmad Azam, Nor Fadilah Rajab, Intan Safinar Ismail, Devinder Kaur Ajit Singh, Suzana Shahar, Maw Pin Tan, Francis Berenbaum
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引用次数: 0
摘要
骨关节炎(OA)通常影响膝关节和髋关节,占全球残疾调整寿命年数和残疾生活年数的19.3%(参考文献1、2)。为了避免残疾,提高生活质量,早期治疗非常重要(参考文献 3)。然而,由于缺乏对OA亚临床和早期症状阶段的认识,往往阻碍了早期治疗(参考文献4)。此外,在病情严重的患者中,OA诊断较晚的情况也很常见,因为此时OA的治疗变得更加复杂(参考文献5、6、7、8)。导致 OA 发生和恶化的既定风险因素包括年龄增长、女性、外伤史和肥胖(参考文献 9)。最近的研究还发现,OA 与代谢综合征之间存在联系,代谢综合征的特征是胰岛素抵抗、血脂异常和高血压(参考文献 10、11)。
Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers
Osteoarthritis (OA) commonly affects the knee and hip joints and accounts for 19.3% of disability-adjusted life years and years lived with disability worldwide (Refs 1, 2). Early management is important in order to avoid disability uphold quality of life (Ref. 3). However, a lack of awareness of subclinical and early symptomatic stages of OA often hampers early management (Ref. 4). Moreover, late diagnosis of OA among those with severe disease, at a stage when OA management becomes more complicated is common (Refs 5, 6, 7, 8). Established risk factors for the development and progression of OA include increasing age, female, history of trauma and obesity (Ref. 9). Recent studies have also drawn a link between OA and metabolic syndrome, which is characterized by insulin resistance, dyslipidaemia and hypertension (Refs 10, 11).
期刊介绍:
Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.