异病同治:白细胞介素-41 及其生物功能

IF 4.9 3区 医学 Q2 IMMUNOLOGY
Immunology Pub Date : 2024-04-09 DOI:10.1111/imm.13791
Runfeng Shi, Meixin He, Yongzheng Peng, Xu Xia
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引用次数: 0

摘要

白细胞介素-41(IL-41)是一种新发现的细胞因子,被命名为 Cometin、Subfatin、meteorin-like transcription(Metrnl)等。它在动物体内广泛表达,可通过自分泌和旁分泌两种形式发挥生物学作用。它具有抗炎、改善机体代谢、调节免疫、调节脂肪代谢等功能,并参与自身免疫性疾病或炎症损伤的过程。它在牛皮癣、糖尿病、克罗恩病(CD)、骨关节炎、川崎病(KD)、巴塞杜氏病、自身免疫性肝炎、不孕症、肥胖症、败血症、心血管疾病和呼吸系统疾病中发挥着重要作用。本文回顾了 IL-41 的生物功能、IL-41 与疾病的关系、IL-41 在细胞因子网络中的作用以及可能的信号通路。为了从异病同治的角度探索同一靶点或同一药物治疗不同疾病,人们提出了基于IL-41的细胞因子策略,用于免疫性疾病和炎症性疾病的精准治疗。值得注意的是,IL-41 相关制剂在肺部保护和戒烟方面的应用也是令人感兴趣的研究领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Homotherapy for heteropathy: Interleukin-41 and its biological functions

Homotherapy for heteropathy: Interleukin-41 and its biological functions

Homotherapy for heteropathy: Interleukin-41 and its biological functions

Interleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Graves' disease, autoimmune hepatitis, infertility, obesity, sepsis, cardiovascular diseases and respiratory diseases. This paper reviews the biological functions of IL-41, the relationship between IL-41 and diseases, the effects of IL-41 in the cytokine network and the possible signalling pathways. In order to explore the same target or the same drug for the treatment of different diseases from the perspective of homotherapy for heteropathy, cytokine strategies based on IL-41 have been put forward for the precise treatment of immune diseases and inflammatory diseases. It is worth noting that IL-41 related preparations for lung protection and smoking cessation are interesting research fields.

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来源期刊
Immunology
Immunology 医学-免疫学
CiteScore
11.90
自引率
1.60%
发文量
175
审稿时长
4-8 weeks
期刊介绍: Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers. Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology. The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.
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