中医药在调节肿瘤微环境中的作用

IF 2.7 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

OncoTargets and therapy Pub Date : 2024-04-10 DOI:10.2147/ott.s444214

Ziwei Wang, Mengyao Li, Ling Bi, Xueqing Hu, Yan Wang

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引用次数: 0

摘要

摘要：肿瘤微环境（TME）是一个复杂的综合系统，包含多种肿瘤浸润免疫细胞和基质细胞。它们与癌细胞密切相关，影响着癌症的发生和发展。中医药是我国治疗癌症的重要辅助疗法。它主要通过调节TME来消除癌细胞。本综述旨在系统总结肿瘤细胞与TME之间的相互关系，总结中医药调控TME的研究进展。该综述对揭示中医药的治疗作用机制具有重要意义，并为中医药与免疫疗法在癌症治疗中的联合应用提供了契机。关键词：癌症；肿瘤微环境；中医药；抗肿瘤作用

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Traditional Chinese Medicine in Regulating Tumor Microenvironment

Abstract: Tumor microenvironment (TME) is a complex and integrated system containing a variety of tumor-infiltrating immune cells and stromal cells. They are closely connected with cancer cells and influence the development and progression of cancer. Traditional Chinese medicine (TCM) is an important complementary therapy for cancer treatment in China. It mainly eliminates cancer cells by regulating TME. The aim of this review is to systematically summarize the crosstalk between tumor cells and TME, and to summarize the research progress of TCM in regulating TME. The review is of great significance in revealing the therapeutic mechanism of action of TCM, and provides an opportunity for the combined application of TCM and immunotherapy in cancer treatment.

Keywords: cancer, tumor microenvironment, traditional Chinese medicine, anti-tumor effects

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来源期刊

OncoTargets and therapy BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ONCOLOGY

CiteScore

9.70

自引率

0.00%

发文量

221

审稿时长

1 months

期刊介绍： OncoTargets and Therapy is an international, peer-reviewed journal focusing on molecular aspects of cancer research, that is, the molecular diagnosis of and targeted molecular or precision therapy for all types of cancer. The journal is characterized by the rapid reporting of high-quality original research, basic science, reviews and evaluations, expert opinion and commentary that shed novel insight on a cancer or cancer subtype. Specific topics covered by the journal include: -Novel therapeutic targets and innovative agents -Novel therapeutic regimens for improved benefit and/or decreased side effects -Early stage clinical trials Further considerations when submitting to OncoTargets and Therapy: -Studies containing in vivo animal model data will be considered favorably. -Tissue microarray analyses will not be considered except in cases where they are supported by comprehensive biological studies involving multiple cell lines. -Biomarker association studies will be considered only when validated by comprehensive in vitro data and analysis of human tissue samples. -Studies utilizing publicly available data (e.g. GWAS/TCGA/GEO etc.) should add to the body of knowledge about a specific disease or relevant phenotype and must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Bioinformatics studies must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Single nucleotide polymorphism (SNP) studies will not be considered.