在动物模型中利用纵向多参数磁共振成像绘制慢性肝病的病理生理学图谱

IF 7 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Investigative Radiology Pub Date : 2024-04-10 DOI:10.1097/rli.0000000000001075

Ferhan Baskaya, Teresa Lemainque, Barbara Klinkhammer, Susanne Koletnik, Saskia von Stillfried, Steven R Talbot, Peter Boor, Volkmar Schulz, Wiltrud Lederle, Fabian Kiessling

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引用次数: 0

摘要

慢性肝病（CLD）的病因多种多样。为了更好地对慢性肝病进行分类，我们探索了纵向多参数磁共振成像（MRI）在小鼠高脂饮食（HFD）和四氯化碳（CCl4）诱导的慢性肝病模型中描述肝脏形态、炎症、肝细胞和巨噬细胞活性变化的能力。

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Pathophysiologic Mapping of Chronic Liver Diseases With Longitudinal Multiparametric MRI in Animal Models.

Chronic liver diseases (CLDs) have diverse etiologies. To better classify CLDs, we explored the ability of longitudinal multiparametric MRI (magnetic resonance imaging) in depicting alterations in liver morphology, inflammation, and hepatocyte and macrophage activity in murine high-fat diet (HFD)- and carbon tetrachloride (CCl4)-induced CLD models.

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来源期刊

Investigative Radiology 医学-核医学

CiteScore

15.10

自引率

16.40%

发文量

188

审稿时长

4-8 weeks

期刊介绍： Investigative Radiology publishes original, peer-reviewed reports on clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, and related modalities. Emphasis is on early and timely publication. Primarily research-oriented, the journal also includes a wide variety of features of interest to clinical radiologists.