壳聚糖敷料用于治疗腭部供体部位:随机临床试验

IF 3.4 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Vikender Singh Yadav, Kanika Makker, Razia Haidrus, Anika Dawar, Bhumika Gumber
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引用次数: 0

摘要

目的 本研究旨在评估壳聚糖基敷料(CD)在接受游离龈移植(FGG)手术的患者腭供体部位实现早期伤口愈合和止血的效果。方法 在这项随机对照临床试验中,32 名需要接受 FGG 的患者接受了治疗。术后第 7、14、21 和 28 天,由一名盲人检查员对供体部位的完全上皮化(CE)和颜色匹配(CM)进行评估。对照组(CG)或试验组(TG)在移植物采集后立即用湿纱布(WG)压迫供体部位 2 分钟,并记录即刻出血(IB)(是/否)。患者每天记录延迟出血(DB)(1 周)、止痛片用量和疼痛 VAS 评分(2 周)。TG组的CE发生率(第2周和第3周)和VAS评分均高于CM评分,但组间差异仅在CM(第4周)方面具有统计学意义。TG组中表现出IB和DB的患者人数明显较少(p <.05)。尽管 5 天内 TG 组的平均疼痛评分和镇痛药用量较高,但在任何时间点两组间的差异均无统计学意义。此外,我们还发现 CD 能明显减少出血并发症,但并未降低疼痛程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chitosan-based dressing for management of palatal donor site: A randomized clinical trial

Aims

This study aimed to evaluate the effectiveness of a chitosan-based dressing (CD) in achieving early wound healing and hemostasis at palatal donor sites in patients undergoing free gingival graft (FGG) surgery.

Methods

Thirty-two patients requiring FGG were treated in this randomized controlled clinical trial. Complete epithelialization (CE) and color match (CM) at donor sites were assessed by a blinded examiner on postoperative days 7, 14, 21, and 28. Donor sites were compressed for 2 min with wet gauze (WG) alone in control group (CG) or WG + CD in test group (TG) immediately after graft harvesting, and immediate bleeding (IB) was recorded (yes/no). Delayed bleeding (DB) (for 1 week), and number of analgesic tablets consumed, and VAS scores for pain (for 2 weeks) were recorded by patient every day.

Results

Twenty-eight patients (14 in each group) were included in final analysis. The prevalence of CE (at weeks 2 and 3) and VAS scores for CM scores were higher in TG but the intergroup differences were statistically significant only for CM (at week 4). Number of patients exhibiting IB and DB was significantly fewer in the TG (p < .05). Although average pain scores and analgesic consumption were higher in TG up to 5 days, differences between two groups were not statistically significant at any time point.

Conclusion

Our data suggests that the application of CD increased re-epithelialization and accelerated wound healing process, although it did not reach statistical significance. Moreover, CD was found to significantly reduce bleeding complications, but it did not decrease the pain levels.

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来源期刊
Journal of periodontal research
Journal of periodontal research 医学-牙科与口腔外科
CiteScore
6.90
自引率
5.70%
发文量
103
审稿时长
6-12 weeks
期刊介绍: The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.
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