牙周病与阿尔茨海默氏症:系统文献网络分析的启示

IF 4.3 Q2 BUSINESS
Alice Villar, S. Paladini, J. Cossatis
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引用次数: 0

摘要

证据 本研究通过系统文献网络分析(SLNA),结合文献计量分析和系统文献综述(SLR),研究了牙周病(PD)和阿尔茨海默病(AD)之间的关系。我们分析了 2000 年至 2023 年的 328 篇文献,利用 Bibliometrix R 软件包进行了多重文献计量分析。系统文献综述主要以全球引用率最高的 47 篇论文为中心,突出了有影响力的研究。我们的研究揭示了牙周病(PD)和阿尔茨海默病(AD)之间的正相关性,这种正相关性建立在生物学合理性和文献综述的基础上,但两者之间的确切因果关系仍是科学界正在研究的课题。我们详细分析了牙周病可能导致脑部炎症的两个主要途径:(a) 炎症级联和 (b) 微生物参与。我们的 SLNA 结果强调了口腔健康对降低阿尔茨海默氏症风险的重要性,表明牙周健康管理可以成为阿尔茨海默氏症预防和治疗策略不可或缺的一部分。这项 SLNA 的见解为未来的研究和临床实践铺平了道路,强调了在调查和治疗阿尔茨海默氏症等神经退行性疾病时采用跨学科方法的必要性。此外,我们的研究还提出了一个前瞻性的研究路线图,以支持该领域的不断进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Periodontal Disease and Alzheimer’s: Insights from a Systematic Literature Network Analysis

Periodontal Disease and Alzheimer’s: Insights from a Systematic Literature Network Analysis

Evidence This study investigated the relationship between periodontal disease (PD) and Alzheimer’s Disease (AD) through a Systematic Literature Network Analysis (SLNA), combining bibliometric analysis with a Systematic Literature Review (SLR). Analyzing 328 documents from 2000 to 2023, we utilized the Bibliometrix R-package for multiple bibliometric analysis. The SLR primarily centered on the 47 most globally cited papers, highlighting influential research. Our study reveals a positive correlation between Periodontal Disease (PD) and Alzheimer’s Disease (AD), grounded in both biological plausibility and a comprehensive review of the literature, yet the exact causal relationship remains a subject of ongoing scientific investigation. We conducted a detailed analysis of the two main pathways by which PD could contribute to brain inflammation: (a) the Inflammatory Cascade, and (b) Microbial Involvement. The results of our SLNA emphasize the importance of oral health in reducing Alzheimer’s risk, suggesting that managing periodontal health could be an integral part of Alzheimer’s prevention and treatment strategies. The insights from this SLNA pave the way for future research and clinical practices, underscoring the necessity of interdisciplinary methods in both the investigation and treatment of neurodegenerative diseases like Alzheimer’s. Furthermore, our study presents a prospective research roadmap to support ongoing advancement in this field.

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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
发文量
0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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