结直肠癌中的一个关键核分枝杆菌支系

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-04-16 DOI:10.1038/s41575-024-00930-3

Katrina Ray

引用次数: 0

摘要

发表在《自然》（Nature）上的一项新研究发现了一个在人类结直肠癌（CRC）生态位中占主导地位的独特的核团镰刀菌支系--Fna C2。重要的是，在小鼠体内，Fna C2 会导致大肠腺瘤数量增加和代谢物谱改变。研究人员从135株F.nucleatum菌株（80株来自非癌症患者的口腔菌株和55株从51名CRC患者的肿瘤中培养出的独特癌症菌株）中生成了封闭基因组，确定了483个富含CRC的遗传因子（相比之下，241个基因簇在口腔菌株中非常普遍）。此外，肿瘤分离菌株主要属于 F. nucleatum subsp. animalis，但进一步的泛基因组分析表明，该亚种实际上由两个不同的支系（Fna C1 和 Fna C2）组成。至关重要的是，Fna C2 支系富集于 CRC 龛位，而 Fna C1 支系则主要局限于口腔，并且与 C1 支系有明显的不同，包括存在额外的毒力因子（包括 fap2、cmpA 和 fusolisin）和不同的形态（Fna C2 细胞更长、更薄）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A crucial Fusobacterium nucleatum clade in colorectal cancer

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A crucial Fusobacterium nucleatum clade in colorectal cancer

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.