Xue Tian , Ye-qing Dong , Jia-yu Yuan , Ying Gao, Chu-hao Zhang, Mei-juan Li, Jie Li
{"title":"外周血浆细胞因子水平与首次发病、未服药的重度抑郁障碍患者自杀意念之间的关系","authors":"Xue Tian , Ye-qing Dong , Jia-yu Yuan , Ying Gao, Chu-hao Zhang, Mei-juan Li, Jie Li","doi":"10.1016/j.psyneuen.2024.107042","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Inflammatory processes could potentially impact both mood and suicide risk, however, the relationship between cytokines and suicidal ideation remains unclear. This study aimed to investigate the association between plasma levels of cytokines and suicidal ideation in population with major depressive disorders (MDD).</p></div><div><h3>Methods</h3><p>A cross-sectional study was performed to assess the peripheral plasma levels of interleukin-1β (IL-1β), IL-2, IL-6, IL-8, IL-10 and tumor necrosis factor-α (TNF-α) in 88 Chinese Han first-episode drug-naïve MDD patients. Suicidal ideation in the past week were identified using the Beck Scale for Suicide Ideation-Chinese Version (BSI-CV). The Hamilton Depression Rating Scale-17 (HAMD-17), the Hamilton Anxiety Rating Scale-14 (HAMA-14) and the Childhood Trauma Questionnaire (CTQ) was used to assess depression, anxiety and childhood trauma. Multivariable logistic regression models were used to estimate the association between cytokines and suicidal ideation. Interaction and stratified analyses were conducted according to age, sex, marital status, education, smoking status, BMI and physical activity.</p></div><div><h3>Results</h3><p>Among the 88 participants, 42 individuals (47.7%) reported suicidal ideation within the past week. In the fully adjusted model, a statistically significant trend was observed in the association between IL-2 level and suicidal ideation (OR: 1.40, 95% CI: 1.00–1.97). The stratified analysis showed a statistically significant association between IL-6 level and suicidal ideation among younger people (OR: 1.17, 95% CI: 1.01–1.36) and a significant positive association between IL-8 (OR: 1.59, 95% CI: 1.03–2.44) and IL-10 (OR: 2.51, 95% CI: 1.27–4.96) levels and suicide ideation among higher educated populations.</p></div><div><h3>Limitations</h3><p>The cross-sectional design, residual confounding effects and small sample size</p></div><div><h3>Conclusion</h3><p>Our findings indicate a significant positive association between plasma IL-2 level and suicidal ideation in MDD patients. IL-2 has the potential to be a biomarker of suicidal ideation in patients with depression.</p></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between peripheral plasma cytokine levels and suicidal ideation in first-episode, drug-naïve major depressive disorder\",\"authors\":\"Xue Tian , Ye-qing Dong , Jia-yu Yuan , Ying Gao, Chu-hao Zhang, Mei-juan Li, Jie Li\",\"doi\":\"10.1016/j.psyneuen.2024.107042\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Inflammatory processes could potentially impact both mood and suicide risk, however, the relationship between cytokines and suicidal ideation remains unclear. This study aimed to investigate the association between plasma levels of cytokines and suicidal ideation in population with major depressive disorders (MDD).</p></div><div><h3>Methods</h3><p>A cross-sectional study was performed to assess the peripheral plasma levels of interleukin-1β (IL-1β), IL-2, IL-6, IL-8, IL-10 and tumor necrosis factor-α (TNF-α) in 88 Chinese Han first-episode drug-naïve MDD patients. Suicidal ideation in the past week were identified using the Beck Scale for Suicide Ideation-Chinese Version (BSI-CV). The Hamilton Depression Rating Scale-17 (HAMD-17), the Hamilton Anxiety Rating Scale-14 (HAMA-14) and the Childhood Trauma Questionnaire (CTQ) was used to assess depression, anxiety and childhood trauma. Multivariable logistic regression models were used to estimate the association between cytokines and suicidal ideation. Interaction and stratified analyses were conducted according to age, sex, marital status, education, smoking status, BMI and physical activity.</p></div><div><h3>Results</h3><p>Among the 88 participants, 42 individuals (47.7%) reported suicidal ideation within the past week. In the fully adjusted model, a statistically significant trend was observed in the association between IL-2 level and suicidal ideation (OR: 1.40, 95% CI: 1.00–1.97). The stratified analysis showed a statistically significant association between IL-6 level and suicidal ideation among younger people (OR: 1.17, 95% CI: 1.01–1.36) and a significant positive association between IL-8 (OR: 1.59, 95% CI: 1.03–2.44) and IL-10 (OR: 2.51, 95% CI: 1.27–4.96) levels and suicide ideation among higher educated populations.</p></div><div><h3>Limitations</h3><p>The cross-sectional design, residual confounding effects and small sample size</p></div><div><h3>Conclusion</h3><p>Our findings indicate a significant positive association between plasma IL-2 level and suicidal ideation in MDD patients. 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Association between peripheral plasma cytokine levels and suicidal ideation in first-episode, drug-naïve major depressive disorder
Background
Inflammatory processes could potentially impact both mood and suicide risk, however, the relationship between cytokines and suicidal ideation remains unclear. This study aimed to investigate the association between plasma levels of cytokines and suicidal ideation in population with major depressive disorders (MDD).
Methods
A cross-sectional study was performed to assess the peripheral plasma levels of interleukin-1β (IL-1β), IL-2, IL-6, IL-8, IL-10 and tumor necrosis factor-α (TNF-α) in 88 Chinese Han first-episode drug-naïve MDD patients. Suicidal ideation in the past week were identified using the Beck Scale for Suicide Ideation-Chinese Version (BSI-CV). The Hamilton Depression Rating Scale-17 (HAMD-17), the Hamilton Anxiety Rating Scale-14 (HAMA-14) and the Childhood Trauma Questionnaire (CTQ) was used to assess depression, anxiety and childhood trauma. Multivariable logistic regression models were used to estimate the association between cytokines and suicidal ideation. Interaction and stratified analyses were conducted according to age, sex, marital status, education, smoking status, BMI and physical activity.
Results
Among the 88 participants, 42 individuals (47.7%) reported suicidal ideation within the past week. In the fully adjusted model, a statistically significant trend was observed in the association between IL-2 level and suicidal ideation (OR: 1.40, 95% CI: 1.00–1.97). The stratified analysis showed a statistically significant association between IL-6 level and suicidal ideation among younger people (OR: 1.17, 95% CI: 1.01–1.36) and a significant positive association between IL-8 (OR: 1.59, 95% CI: 1.03–2.44) and IL-10 (OR: 2.51, 95% CI: 1.27–4.96) levels and suicide ideation among higher educated populations.
Limitations
The cross-sectional design, residual confounding effects and small sample size
Conclusion
Our findings indicate a significant positive association between plasma IL-2 level and suicidal ideation in MDD patients. IL-2 has the potential to be a biomarker of suicidal ideation in patients with depression.
期刊介绍:
Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.