被遗忘的噩梦再次降临:百日咳博德特菌利用更负的吉布斯代谢能战胜宿主生物

IF 3 4区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES
Marko E. Popović , Maja Stevanović , Marijana Pantović Pavlović
{"title":"被遗忘的噩梦再次降临:百日咳博德特菌利用更负的吉布斯代谢能战胜宿主生物","authors":"Marko E. Popović ,&nbsp;Maja Stevanović ,&nbsp;Marijana Pantović Pavlović","doi":"10.1016/j.mran.2024.100292","DOIUrl":null,"url":null,"abstract":"<div><p>Pertussis (whooping cough) has been nearly eradicated during the 20th century, first of all due to an organized and comprehensive vaccination campaign that lasted for decades. Generations of doctors educated in Serbia (and other countries) rarely had an opportunity to see the clinical picture of pertussis. However, during 2023, the number of registered cases of pertussis in Serbia has increased several times. This is why the health authorities were forced to declare danger of an epidemic. During 2023, in Belgrade, around 1000 cases were registered. During the two months of 2024, 400 cases were registered. Some of them have ended with lethal outcome. This paper reports for the first time the biosynthesis reaction and thermodynamic properties of biosynthesis (enthalpy, entropy and Gibbs energy) of <em>Bordetella pertussis</em>, the cause of whooping cough. Moreover, a mechanistic model of multiplication of <em>B. pertussis</em> was developed. The mechanistic model was related to the pathogenesis of pertussis.</p></div>","PeriodicalId":48593,"journal":{"name":"Microbial Risk Analysis","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Return of the forgotten nightmare: Bordetella pertussis uses a more negative Gibbs energy of metabolism to outcompete its host organism\",\"authors\":\"Marko E. Popović ,&nbsp;Maja Stevanović ,&nbsp;Marijana Pantović Pavlović\",\"doi\":\"10.1016/j.mran.2024.100292\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Pertussis (whooping cough) has been nearly eradicated during the 20th century, first of all due to an organized and comprehensive vaccination campaign that lasted for decades. Generations of doctors educated in Serbia (and other countries) rarely had an opportunity to see the clinical picture of pertussis. However, during 2023, the number of registered cases of pertussis in Serbia has increased several times. This is why the health authorities were forced to declare danger of an epidemic. During 2023, in Belgrade, around 1000 cases were registered. During the two months of 2024, 400 cases were registered. Some of them have ended with lethal outcome. This paper reports for the first time the biosynthesis reaction and thermodynamic properties of biosynthesis (enthalpy, entropy and Gibbs energy) of <em>Bordetella pertussis</em>, the cause of whooping cough. Moreover, a mechanistic model of multiplication of <em>B. pertussis</em> was developed. The mechanistic model was related to the pathogenesis of pertussis.</p></div>\",\"PeriodicalId\":48593,\"journal\":{\"name\":\"Microbial Risk Analysis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microbial Risk Analysis\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352352224000033\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbial Risk Analysis","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352352224000033","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

百日咳(百日咳)在 20 世纪几乎被根除,这首先要归功于持续数十年的有组织的全面疫苗接种运动。在塞尔维亚(和其他国家)接受教育的几代医生很少有机会看到百日咳的临床表现。然而,在 2023 年期间,塞尔维亚登记的百日咳病例数增加了数倍。因此,卫生当局被迫宣布有流行病的危险。2023 年期间,贝尔格莱德登记的病例约为 1 000 例。在 2024 年的两个月里,登记了 400 个病例。其中一些病例最终导致死亡。本文首次报道了百日咳病原体百日咳杆菌的生物合成反应和生物合成的热力学特性(焓、熵和吉布斯能)。此外,还建立了百日咳杆菌的繁殖机理模型。该机理模型与百日咳的发病机制有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Return of the forgotten nightmare: Bordetella pertussis uses a more negative Gibbs energy of metabolism to outcompete its host organism

Pertussis (whooping cough) has been nearly eradicated during the 20th century, first of all due to an organized and comprehensive vaccination campaign that lasted for decades. Generations of doctors educated in Serbia (and other countries) rarely had an opportunity to see the clinical picture of pertussis. However, during 2023, the number of registered cases of pertussis in Serbia has increased several times. This is why the health authorities were forced to declare danger of an epidemic. During 2023, in Belgrade, around 1000 cases were registered. During the two months of 2024, 400 cases were registered. Some of them have ended with lethal outcome. This paper reports for the first time the biosynthesis reaction and thermodynamic properties of biosynthesis (enthalpy, entropy and Gibbs energy) of Bordetella pertussis, the cause of whooping cough. Moreover, a mechanistic model of multiplication of B. pertussis was developed. The mechanistic model was related to the pathogenesis of pertussis.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Microbial Risk Analysis
Microbial Risk Analysis Medicine-Microbiology (medical)
CiteScore
5.70
自引率
7.10%
发文量
28
审稿时长
52 days
期刊介绍: The journal Microbial Risk Analysis accepts articles dealing with the study of risk analysis applied to microbial hazards. Manuscripts should at least cover any of the components of risk assessment (risk characterization, exposure assessment, etc.), risk management and/or risk communication in any microbiology field (clinical, environmental, food, veterinary, etc.). This journal also accepts article dealing with predictive microbiology, quantitative microbial ecology, mathematical modeling, risk studies applied to microbial ecology, quantitative microbiology for epidemiological studies, statistical methods applied to microbiology, and laws and regulatory policies aimed at lessening the risk of microbial hazards. Work focusing on risk studies of viruses, parasites, microbial toxins, antimicrobial resistant organisms, genetically modified organisms (GMOs), and recombinant DNA products are also acceptable.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信