肠道微生物群与帕金森病轻度认知障碍无关

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2024-04-06 DOI:10.1038/s41531-024-00687-1

Velma T. E. Aho, Matthias Klee, Zied Landoulsi, Anna Heintz-Buschart, Lukas Pavelka, Anja K. Leist, Rejko Krüger, Patrick May, Paul Wilmes

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引用次数: 0

摘要

帕金森病（PD）患者与无帕金森病的对照组之间的肠道微生物组差异已被广泛报道，但与帕金森病伴轻度认知障碍（MCI）有关的潜在改变尚未得到全面探讨。我们比较了患有 MCI 的帕金森病患者（58 人）与认知功能未受损的帕金森病患者（60 人）和认知功能正常的对照组受试者（90 人）的肠道微生物特征。我们的研究结果不支持与帕金森病 MCI 相关的特定微生物组特征。

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Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.