细辛对卡拉胶诱导的 Wistar 雄性大鼠爪水肿的抗炎活性

Q3 Pharmacology, Toxicology and Pharmaceutics

Research Journal of Pharmacy and Technology Pub Date : 2024-01-19 DOI:10.52711/0974-360x.2024.00031

Himanshi Himanshi, Pushpraj S Gupta

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引用次数: 0

摘要

炎症是人体的生理防御系统，可启动组织愈合机制，消除伤害性刺激。在本研究中，我们评估了细叶叶枯素的抗炎活性。以苯丁酮为标准药物，在卡拉胶诱导的大鼠爪水肿模型中研究了水提取物（250 毫克/千克，体重）和分离多糖（500 毫克/千克，体重）。水提取物和分离多糖都通过阻断环氧化酶 2 通路而显示出显著的抗炎活性。这是第一份证明细叶木通草具有体内抗炎活性的报告。

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Anti-inflammatory activity of Codium elongatum on Carrageenan-induced paw edema in Wistar male rats

Inflammation is the physiological defence system of the body to initiate the healing mechanism for tissue and eliminate injurious stimuli. In the present study, the anti-inflammatory activity of Codium elongatum was evaluated. Water extract (250 mg/kg, b.w.) and isolated polysaccharide (500 mg/kg, b.w.) are investigated in the carrageenan-induced rat paw edema model using phenylbutazone as a standard drug. Both water extract and isolated polysaccharide showed significant anti-inflammatory activity by blocking the cyclooxygenase 2 pathway. This is the first report to demonstrate the in-vivo anti-inflammatory activity of Codium elongatum.

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来源期刊

Research Journal of Pharmacy and Technology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.