琥珀酸舒马曲普坦半乙醇溶液

Molbank Pub Date : 2024-01-26 DOI:10.3390/m1766

Petr A. Buikin, A. Vologzhanina, Alexander A. Korlyukov

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引用次数: 0

摘要

1-(3-(2-(二甲基氨基)乙基)-1H-吲哚-5-基)-N-甲基甲磺酰胺琥珀酸盐（琥珀酸舒马曲普坦，HSum+-HSucc-）是一种血清素受体激动剂，用于治疗偏头痛。通过从乙醇中重结晶这种物质，得到了它的半乙醇溶物 HSum+-HSucc--0.5EtOH。通过 X 射线衍射和傅立叶变换红外光谱对这种固体进行了表征。在 HSum+-HSucc--0.5EtOH 中，溶剂分子将琥珀酸阴离子连接成无限的 O-H...O 键链，这些链通过 N-H...O 与阳离子的相互作用进一步连接成 H 键层。

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Sumatriptan Succinate Hemi(Ethanol Solvate)

1-(3-(2-(Dimethylammonio)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide succinate (sumatriptan succinate, HSum+·HSucc−) is a serotonin receptor agonist used to treat migraines. By the recrystallization of this substance from ethanol, its hemi(ethanol solvate), HSum+·HSucc−·0.5EtOH, was obtained. The solid was characterized by X-ray diffraction and FT-IR spectroscopy. In HSum+·HSucc−·0.5EtOH, solvent molecules link succinate anions into infinite O–H…O bonded chains, which are further connected by N–H…O interactions with cations into H-bonded layers.

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Molbank

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