EXPERIMENTAL EVALUATION OF VAJIKARANA KARMA OF TILAGOKSHURA SIDDA DUGDA WITH SPECIAL REFERENCE TO APHRODISIAC ACTIVITY

Infertility is a disease of the male or female reproductive system defined by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse. Estimates suggest that approximately one in every six people of reproductive age worldwide experience infertility in their lifetime. Conventional management need long term therapy and are not devoid of ADR’s. Vajikarana is one among Astanga Ayurveda that deals with the preservation and amplification of sexual potency of a healthy man and conception of healthy progeny. Vajikarana yogas helpful in management of Shukra dusti and Vandytava were documented in the classics. ‘TilaGokshura Sidda Dugdha’ is one such formulation explained by Chakradatta in Vajikarana chapter indicat-ed in Shandatva (Impotency). The ingredients of yoga are Tila and Gokshura processed in Aja ksheera (Gaot milk) which are having Shukrala and Vrishya karma. Thus, yoga was selected to evaluate the Vajikarana karma. Also, an additional attempt is made to evaluate the same yoga by changing the processing agent as Go-Dugda(Cow milk) in another group. MATERIAL AND METHODS : Wister rats were grouped in to 5 groups of 6 animals each. Experimental period was 28 days study. Oligospermia was induced by administrating Metroni-dazole for initial 14 days. Group one as Normal, Group 2 as Disease control, Group 3 was treated with Clomi-phene citrate, Group 4 and Group 5 were treated with Tila Gokshura Sidda Dugda (Aja Dugda Saditha) and Tila Gokshura Sidda Dug-da (Go-Dugda Saditha) respectively for next 14 days. Sexual Behaviour Pattern, Sperm count, Serum parameters, Tissue parameters and Histopathological changes in testis tissue were Observed. DIS-CUSSIONS AND CONCLUSION : Tila Gokshura Sidda Dugda (Aja Dugda Saditha) showed effective Vajika-rana karma in experimental rats when compared to standard drug. RESULTS : The results of the experimental study reveal that TilaGokshura Sidda Dugda has significant Vajikarana karma when compared with standard drug.