Diagnostic Test Accuracy of the YEARS Algorithm for Pulmonary Embolism

This systematic review and meta-analysis aimed to evaluate both the diagnostic test accuracy of the YEARS algorithm in excluding pulmonary embolism and to compare the advance imaging utilisation rate of YEARS against standard practice. Published studies were selected across several databases from July 2017 to September 2022 using Joanna Briggs Institute methodology for systematic reviews of diagnostic accuracy. The analysis included ten studies with nearly 14,000 participants. YEARS showed a sensitivity of 96% (95% CI 93-98%) and specificity of 50% (95% CI 33-67%). The risk ratio for advanced imaging was 0.78 (95% CI 67-90), showing an overall reduction. YEARS is an effective means of safely managing patients with suspected pulmonary embolism. Keywords: Pulmonary Embolism; Diagnostic Imaging; Fibrin Fragment D; Meta-Analysis; Systematic Review; Fibrin Fibrinogen Degradation Products; Clinical Decision Rules.