利用高效纳米催化剂合成的吖啶具有高效生物活性

Q4 Earth and Planetary Sciences

Research Journal of Chemistry and Environment Pub Date : 2024-01-31 DOI:10.25303/283rjce056060

G. Sujatha, Devi A. Mathunika, Josephine J. Lesy, P. Punitha, P. Ramanathan

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引用次数: 0

摘要

利用高效纳米催化剂，采用传统方法合成了一种简单高效的 9-(4-甲氧基苯基)-3,3,6,6-四甲基-3,4,6,7,9,10-六氢吖啶-1,8(2H,5H)-二酮（MPTH）。TiO2 的晶粒尺寸（L）和表面积（S）分别为 10.44 nm 和 140.32 m2/g。MPTH 对 KB 细胞表现出广泛的抑制作用，IC50 值为 25.06 μg。MPTH 的 IC50 值意味着甲氧基取代的化合物对癌细胞具有更强的抑制作用。

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Efficient biological activity of acridine synthesised by using efficient nano catalyst

A simple and efficient protocol for 9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexa hydroacridine-1,8(2H,5H)-dione (MPTH) was synthesised by conventional method by using efficient nano catalyst. The crystallite sizes (L) and surface area (S) of TiO2 are 10.44 nm and 140.32 m2/g. MPTH displayed wide inhibitions on the KB cell appearance with IC50 values 25.06 μg. The IC50 values of the MPTH imply that methoxy substituted compound holds more inhibitory effect against the cancer cells.

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来源期刊

Research Journal of Chemistry and Environment 化学-化学综合

CiteScore

0.50

自引率

0.00%

发文量

195

审稿时长

4-8 weeks

期刊介绍： Information not localized