靶向 PI3K/AKT 信号通路的 miRNA 在肺癌发病机制中的调控作用

IF 0.2 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Research Journal of Biotechnology Pub Date : 2024-01-31 DOI:10.25303/1903rjbt1350141

K. Sharanya, A.K.A. Mandal

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引用次数: 0

摘要

在当代世界，肺癌已成为人类最常见的癌症类型。最近的研究发现，肺癌的扩散与微小核糖核酸（miRNA）失调有关。一些研究发现，PI3K/AKT 信号通路是某些 miRNA 的关键靶点，在肺癌细胞侵袭和转移的细胞活动中发挥着基础作用。对于肺癌研究来说，miRNAs 及其相互关联的靶基因可能是诊断和治疗肺癌的新领域。本综述重点介绍了靶向 PI3K/AKT 信号通路的调控 miRNA 在肺癌发生中的作用。

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Regulatory effects of miRNAs targeting PI3K/AKT signaling pathway in the pathogenesis of lung cancer

In the contemporary world, lung cancer has become the most frequent type of cancer in humankind. Recent studies revealed that lung cancer proliferation is correlated with microRNA (miRNA) dysregulation. Several studies have identified PI3K/AKT signaling pathway as the key target of certain miRNAs and play a fundamental role in cellular activities involved in lung cancer cell invasion and metastasis. For lung cancer research, miRNAs and their interrelated target genes could be a capable novel field in its diagnosis as well as in therapy. This review highlights the role of regulatory miRNAs targeting the PI3K/AKT signaling pathway in lung carcinogenesis.

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来源期刊

Research Journal of Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

0.60

自引率

0.00%

发文量

192

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