通过植入前非整倍体基因检测被归类为马赛克胚胎的染色体、妊娠和新生儿结果

M. Viotti, E. Greco, James A. Grifo, M. Madjunkov, Clifford Librach, M. Çetinkaya, S. Kahraman, Pavel Yakovlev, Nikolay Kornilov, Laura Corti, A. Biricik, E. Cheng, Ching-Ya Su, Maw-Sheng Lee, Michael D. Bonifacio, Amber R. Cooper, Darren K. Griffin, Diane Y. Tran, Purvi Kaur, Frank L. Barnes, C. Zouves, A. Victor, A. Besser, S. Madjunkova, F. Spinella
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引用次数: 0

摘要

(摘自 Fertil Steril 2023;120(5):957)有丝分裂过程中的染色体分离错误会导致胚胎嵌合,这是一种在单个胚胎中存在不同染色体拷贝数的现象。对多细胞活检组织进行非整倍体植入前基因检测(PGT-A)可在这些病例中产生中间拷贝数,即一些细胞为双倍体,一些细胞为单倍体或三倍体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chromosomal, Gestational, and Neonatal Outcomes of Embryos Classified as a Mosaic by Preimplantation Genetic Testing for Aneuploidy
(Abstracted from Fertil Steril 2023;120(5):957) Chromosomal segregation errors during mitosis can result in embryonic mosaicism, a phenomenon where different chromosomal copy numbers exist within a single embryo. Preimplantation genetic testing for aneuploidy (PGT-A) of multicellular biopsies can produce intermediate copy numbers in these cases, where some cells are disomic and some show monosomy or trisomy.
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