多发性骨髓瘤中参与 TP53 通路关键细胞过程的 18 个基因的表达模式

IF 1 Q3 MULTIDISCIPLINARY SCIENCES

gazi university journal of science Pub Date : 2024-02-13 DOI:10.35378/gujs.1365179

G. Öztan, Ilknur Suer, Aynur Dağlar Aday, M. Ayer, Ş. Öztürk, K. Çefle, M. Yenerel, H. Issever, S. Palanduz

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引用次数: 0

摘要

多发性骨髓瘤（MM）是一种涉及骨髓浆细胞异常产生免疫球蛋白的癌症疾病。文献尚未完全阐明 MM 与 TP53 通路之间的关系。调查 TP53 通路中基因的表达对多发性骨髓瘤疾病的分子发病机制和预后的影响。我们通过RT2-profiler PCR阵列技术评估了48名MM患者和31名健康受试者中TP53通路中18个基因的表达，并研究了它们与细胞遗传学畸变存在的可能关联。结果发现，与对照组相比，18个基因中有12个（APAF1、ATM、BAX、CASP9、CDK4、CDKN1A、CDKN2A、E2F1、MCL1、MDM2、MDM4、PTEN）在MM患者中的表达水平呈统计学上调。研究发现，CDK4、CDKN1A 和 MCL1 基因在区分 MM 和健康对照组方面具有显著的诊断能力（AUC=0.89；AUC=0.86；AUC=0.77，分别为 0.89、0.86、0.77、0.77）。

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Expression patterns of eighteen genes involved in crucial cellular processes in the TP53 pathway in Multiple Myeloma

Multiple myeloma (MM) is a cancerous disease that involves abnormal production of immunoglobulins by bone marrow plasma cells. The relationship between MM and the TP53 pathway has not been fully elucidated in the literature. Investigation of the effect of the expression of genes in the TP53 pathway on the molecular pathogenesis and prognosis of multiple myeloma disease. We assessed the expression of 18 genes in the TP53 pathway in 48 MM patients and 31 healthy subjects by RT2-profiler PCR array technique, and investigated their possible association with the presence of cytogenetic aberrations. Twelve of the 18 genes (APAF1, ATM, BAX, CASP9, CDK4, CDKN1A, CDKN2A, E2F1, MCL1, MDM2, MDM4, PTEN) expression levels were found to be statistically up-regulated in MM patients compared to controls. The CDK4, CDKN1A and MCL1 genes were found to have remarkable diagnostic power distinguishing MM and healthy controls (AUC=0.89;AUC=0.86;AUC=0.77, respectively and p

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来源期刊

gazi university journal of science MULTIDISCIPLINARY SCIENCES-

CiteScore

1.60

自引率

11.10%

发文量

期刊介绍： The scope of the “Gazi University Journal of Science” comprises such as original research on all aspects of basic science, engineering and technology. Original research results, scientific reviews and short communication notes in various fields of science and technology are considered for publication. The publication language of the journal is English. Manuscripts previously published in another journal are not accepted. Manuscripts with a suitable balance of practice and theory are preferred. A review article is expected to give in-depth information and satisfying evaluation of a specific scientific or technologic subject, supported with an extensive list of sources. Short communication notes prepared by researchers who would like to share the first outcomes of their on-going, original research work are welcome.