{"title":"耳部扁平型 BCC:部分截除耳廓是适当的皮肤外科手术方法","authors":"Hristova A, Ivanol L, Tchernev G","doi":"10.15226/2378-1726/11/1/001155","DOIUrl":null,"url":null,"abstract":"Non-melanoma skin cancer is the most common cancer in the world (1). Basal cell carcinoma (BCC) is the most common malignant neoplasia of the skin, accounting for approximately 80% of all cutaneous tumors (2). High cumulative ultraviolet (UV) light exposure and the presence of Fitzpatrick skin phototype I or II are pathogenetic risk factors (3). UV radiation induces mutations in the tumor suppressor PTCH1 gene, leading to increased Hedgehog (XX/Hh) signaling pathway activity (4). Dysfunction or abnormal activation of the Hedgehog signaling pathway is associated with disorders of embryonic development and the development of cancers such as Goltz–Gorlin syndrome for example (5). BCC has the characteristics of a locally invasive, slow-growing skin cancer, with a metastatic incidence between 0.0028-0.5%, with areas in the head and neck most commonly affected (6). Metatypical basal cell carcinoma (MTBCC) is a rare variant of BCC that has histopathological characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) (7).","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"256 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Metatypical BCC of The Ear: Partial Amputation of The Auricle as Adequate Dermatosurgical Approach\",\"authors\":\"Hristova A, Ivanol L, Tchernev G\",\"doi\":\"10.15226/2378-1726/11/1/001155\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Non-melanoma skin cancer is the most common cancer in the world (1). Basal cell carcinoma (BCC) is the most common malignant neoplasia of the skin, accounting for approximately 80% of all cutaneous tumors (2). High cumulative ultraviolet (UV) light exposure and the presence of Fitzpatrick skin phototype I or II are pathogenetic risk factors (3). UV radiation induces mutations in the tumor suppressor PTCH1 gene, leading to increased Hedgehog (XX/Hh) signaling pathway activity (4). Dysfunction or abnormal activation of the Hedgehog signaling pathway is associated with disorders of embryonic development and the development of cancers such as Goltz–Gorlin syndrome for example (5). BCC has the characteristics of a locally invasive, slow-growing skin cancer, with a metastatic incidence between 0.0028-0.5%, with areas in the head and neck most commonly affected (6). Metatypical basal cell carcinoma (MTBCC) is a rare variant of BCC that has histopathological characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) (7).\",\"PeriodicalId\":15481,\"journal\":{\"name\":\"Journal of Clinical Research in Dermatology\",\"volume\":\"256 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Research in Dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15226/2378-1726/11/1/001155\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Research in Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15226/2378-1726/11/1/001155","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
非黑色素瘤皮肤癌是世界上最常见的癌症(1)。基底细胞癌(BCC)是最常见的皮肤恶性肿瘤,约占所有皮肤肿瘤的 80%(2)。大量紫外线(UV)累积照射和菲茨帕特里克皮肤光型 I 或 II 是致病风险因素(3)。紫外线辐射会诱导肿瘤抑制因子 PTCH1 基因突变,导致刺猬(XX/Hh)信号通路活性增强(4)。刺猬信号通路的功能障碍或异常激活与胚胎发育障碍和癌症的发生有关,例如戈尔茨-戈林综合征(Goltz-Gorlin syndrome)(5)。BCC 具有局部浸润、生长缓慢的皮肤癌特征,转移发生率在 0.0028-0.5% 之间,头颈部最常受累(6)。偏典型基底细胞癌(MTBCC)是 BCC 的一种罕见变异型,具有基底细胞癌(BCC)和鳞状细胞癌(SCC)的组织病理学特征(7)。
Metatypical BCC of The Ear: Partial Amputation of The Auricle as Adequate Dermatosurgical Approach
Non-melanoma skin cancer is the most common cancer in the world (1). Basal cell carcinoma (BCC) is the most common malignant neoplasia of the skin, accounting for approximately 80% of all cutaneous tumors (2). High cumulative ultraviolet (UV) light exposure and the presence of Fitzpatrick skin phototype I or II are pathogenetic risk factors (3). UV radiation induces mutations in the tumor suppressor PTCH1 gene, leading to increased Hedgehog (XX/Hh) signaling pathway activity (4). Dysfunction or abnormal activation of the Hedgehog signaling pathway is associated with disorders of embryonic development and the development of cancers such as Goltz–Gorlin syndrome for example (5). BCC has the characteristics of a locally invasive, slow-growing skin cancer, with a metastatic incidence between 0.0028-0.5%, with areas in the head and neck most commonly affected (6). Metatypical basal cell carcinoma (MTBCC) is a rare variant of BCC that has histopathological characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) (7).