Changes in hormonal status after restrictive bariatric interventions

The purpose of the work was to study the impact of bariatric surgeries on hormonal status in patients with morbid obesity. The ghrelin levels were evaluated in 26 morbidly obese patients who underwent restrictive bariatric surgeries (13 gastric plications and 13 gastric sleeve resections). The initial level of ghrelin in the blood of the patients with morbid obesity was lower compared to the levels observed with normal body weight. We did not observe the reduction of ghrelin level expected after the resection of the fundus ghrelin-producing part of the stomach. The clinical study indicates that changes in gastric volume after restrictive bariatric interventions (sleeve resection or gastric plication) are accompanied by a slight increase in blood ghrelin levels. This increase is greater the higher the percentage of body weight loss after surgery. More in-depth study of this topic will help identify new strategies for treating morbid obesity in the future.