阴道微生物群与宫颈癌

José Núñez-Troconis, Antonio Molero
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引用次数: 0

摘要

这篇叙述性综述分析了宫颈癌与阴道微生物组之间的关系。据估计,15% 的癌症是由病毒和细菌引起的。分子生物学、遗传学的发展以及高通量基因组测序技术的使用,使我们不仅能够了解阴道微生物组的表型成分,还能了解其遗传成分,并对以前无法确定的阴道菌群行为有了更好的认识和理解。阴道菌群的改变与妇女的生活习惯、免疫状态和社会经济水平之间的关系已经确定。通过电子方式在 PubMed、Medline、ISI、DOAJ、Springer、Embase、Web of Knowledge 和 Google Scholar 搜索英文原文,并在 Sci-elo、Latindex、Imbiomed-L、Redalyc 和 Google Scholar 搜索西班牙文原文。这篇叙述性综述的目的是研究和分析有关阴道微生物组的改变、其局部保护作用以及可能导致宫颈癌发生的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbiota vaginal y cáncer de cuello uterino.
This narrative review analyzed the relationship between cervical cancer and the vaginal microbiome. It has been estimated that viruses and bac-teria cause 15% of all cancers. The development of molecular biology, genetics, and the use of high-throughput genomic sequencing techniques has allowed us not only to know the phenotypic component but also the genetic component of the vaginal microbiome and obtain a better knowledge and understanding of the behavior of the vaginal flora that was previously impossible to determine. The relation of the alterations in the vaginal flora by women’s habits, immunological status, and socioeconomic level has been established. Literature searches were performed electronically in PubMed, Medline, ISI, DOAJ, Springer, Embase, Web of Knowledge, and Google Scholar for original articles written in English and Sci-elo, Latindex, Imbiomed-L, Redalyc, and Google Scholar for original articles writ-ten in Spanish. The objective of this narrative review was to examine and analyze the literature on the alterations in the vaginal microbiome, their local protective effect and their possible contribution to the development of cervical cancer.
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