利用 BIOPEP-UWM 数据库预测食品蛋白质作为生物肽来源的潜力

A. Iwaniak, M. Darewicz, P. Minkiewicz
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引用次数: 0

摘要

从食物蛋白质中提取的肽具有多种生物活性,如抑制血管紧张素转换酶(ACE;EC 3.4.15.1)、二肽基肽酶 IV(DPP4;EC 3.4.14.5)、α-葡萄糖苷酶(EC 3.2.1.20)、α-淀粉酶(EC 3.2.1.1)等、以及抗氧化、免疫调节和抗血栓等功能。肽的上述抑制功能与调节血压水平(ACE 抑制剂)和血糖浓度(DPP IV、α-葡萄糖苷酶、α-淀粉酶抑制剂)有关。因此,生物活性肽被认为是在预防高血压、2 型糖尿病和/或代谢综合征等方面发挥重要作用的食品成分。计算机技术的发展促进了有助于从理论上预测食品成分特性的工具的开发。这种方法被称为硅学分析,已成为研究蛋白质和肽的三种方法之一。与依靠实验室程序从食品中提取肽的传统方法相比,硅学分析成本更低,耗时更短。因此,本研究旨在介绍 BIOPEP-UWM ® 蛋白质和生物活性肽序列数据库中的可用选项,这些选项可用于评估作为生物活性肽来源的蛋白质。这些选项可以在 BIOPEP-UWM 数据库中的任何蛋白质序列上进行示例。这些选项包括详细描述蛋白质的潜在生物活性概况、蛋白质中具有特定活性的肽的出现频率,以及使用定性和定量标准预测蛋白质中生物肽的酶解情况。此外,还将介绍该数据库的搜索选项以及新的更新内容。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prediction of the Potential of Food Proteins as Sources of Biopeptides Using BIOPEP-UWM Database
: Peptides derived from food proteins exhibit a variety of bioactivities, such as the inhibition of angiotensin converting enzyme (ACE; EC 3.4.15.1), dipeptidyl peptidase IV (DPP4; EC 3.4.14.5), α -glucosidase (EC 3.2.1.20), α -amylase (EC 3.2.1.1), etc., as well as antioxidative, immunomodulating, and antithrombotic functions, etc. The above-mentioned inhibitory functions of peptides are related to the regulation of blood pressure level (ACE inhibitors) and blood glucose concentration (DPP IV, α -glucosidase, α -amylase inhibitors). Thus, bioactive peptides are considered as food components that play an important role in the prevention of, e.g., hypertension, type 2 diabetes, and/or metabolic syndrome. Progress in the development of computer technologies has contributed to the elaboration of tools that are useful in the theoretical prediction of the properties of food components. Such methodologies are called in silico analyses and have become one of the three approaches applied in the study of proteins and peptides. In silico analyses are less costly and time-consuming when compared to classical approaches relying on the involvement of laboratory procedures to produce peptides from food. Thus, the aim of this study is to present the options available in the BIOPEP-UWM ® database of proteins and bioactive peptide sequences that can be useful in the evaluation of proteins as sources of bioactive peptides. Such options can be exemplified on any protein sequence available in the BIOPEP-UWM database. They include the elaboration of the profile of the potential biological activity of a protein, the frequency of the occurrence of peptides with a given activity within a protein, and the prediction of the enzymatic release of biopeptides from a protein using qualitative and quantitative criteria. Moreover, the search options of this database, as well as new updates, will be presented.
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