使用传统合成改变病情药物治疗的早期类风湿关节炎的放射学进展和放射学进展预测因素

IF 0.5 Q4 RHEUMATOLOGY

Indian Journal of Rheumatology Pub Date : 2024-02-23 DOI:10.1177/09733698241229936

Taral Parikh, S. Yadav, C. Balakrishnan

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引用次数: 0

摘要

研究印度早期类风湿性关节炎（RA）患者队列中一年后放射学进展的临床和血清学预测因素。在这项前瞻性开放标签观察研究中，对连续的早期类风湿关节炎患者（<6个月）进行了基线检查，并在每次就诊（0、3、6、9和12个月）时检查疾病活动度、DAS ESR 28和欧洲抗风湿联盟反应。在基线和治疗一年时对手部和足部进行了放射学检查，并使用范德海德夏普评分法评估放射学进展。预后因素采用逻辑回归模型进行评估。对51名符合条件的患者进行了疾病结果分析，对43名符合条件的患者进行了放射学进展分析。RA的平均病程为（3.4 ± 1.85）个月。基线时，96%的患者具有中度至高度疾病活动性。一年后，出现侵蚀的患者比例从16.3%增至37.2%，而出现关节间隙狭窄（JSN）的患者比例从21%增至39.5%。一年后，夏普总评分的平均增幅为 1.67，32.5% 的患者出现放射学进展。基线时的发病年龄、有无糜烂、JSN、抗瓜氨酸蛋白抗体（ACPA）滴度和关节压痛计数与一年后的放射学进展有关。然而，在多变量分析中，没有一个变量能预测放射学损害。只有 JSN 与一年后的进展呈正相关。发病年龄、有无糜烂、JSN、ACPA滴度和基线时的关节触痛计数与一年后的放射学进展有关，但这些结果还需要进一步的研究来证实。

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Radiological Progression and Predictors of Radiological Progression in Early Rheumatoid Arthritis Treated with Conventional Synthetic Disease-modifying Agents

To study the clinical and serological predictors of radiological progression at one year in a cohort of Indian patients with early rheumatoid arthritis (RA). In this prospective open-label observational study, consecutive patients with early RA (

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来源期刊

Indian Journal of Rheumatology RHEUMATOLOGY-

CiteScore

1.10

自引率

14.30%

发文量

审稿时长

13 weeks

期刊介绍： The Indian Journal of Rheumatology (IJR, formerly, Journal of Indian Rheumatology Association) is the official, peer-reviewed publication of the Indian Rheumatology Association. The Journal is published quarterly (March, June, September, December) by Elsevier, a division of Reed-Elsevier (India) Private Limited. It is indexed in Indmed and Embase. It is circulated to all bona fide members of IRA and subscribers.

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