晚期新生儿败血症的妊娠年龄、出生体重和血培养微生物模式

IF 0.2 Q4 PEDIATRICS
Muhammad Ramadhika, Stephen Diah Iskandar, Ivana Yapiy, Yurika Elizabeth Susanti, Marcella Amadea Wijaya, R. Rohsiswatmo
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引用次数: 0

摘要

背景 据世界卫生组织(WHO)称,在印度尼西亚,新生儿死亡的三大主要原因是败血症、早产和窒息。不理想的医院环境会增加晚发新生儿败血症(LONS)的风险,进而延长住院时间。目的 评估新生儿细菌模式与 LONS、早产和/或低出生体重之间可能存在的关联。方法 对 2020 年在雅加达 Cipto Mangunkusumo 医生医院(CMH)新生儿科接受败血症或其他疾病治疗的 1,706 名住院新生儿的病历数据进行回顾性分析。共有262名新生儿被证实患有LONS。我们评估了可能的风险因素,如胎龄、出生体重和培养出的血液微生物。结果 在新生儿科收治的 1706 名新生儿中,经证实的 LONS 发生率为 15.4%。早产儿(58.4%)比足月新生儿(41.6%)更容易感染 LONS。大多数(67.6%)被证实患有LONS的新生儿为低出生体重(LBW)新生儿(<2,500克),其中1,500-2,500克组所占比例最大(35.1%)。革兰氏阴性菌是本院 LONS 患者的主要病原体,其中最常见的是肺炎克雷伯菌、醋氨梭菌属、大肠埃希菌、肠杆菌属和铜绿假单胞菌。结论 与出生体重正常的新生儿相比,低体重儿和早产儿的 LONS 比例明显较高。在我院,LONS 主要由革兰氏阴性菌引起。应检测在 CMH 引起 LONS 的各种病原体的抗生素敏感性,并与 CMH 目前使用的经验性抗生素指南进行比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gestational age, birth weight, and blood culture microbial patterns in late-onset neonatal sepsis
Background The three main  causes of neonatal deaths in Indonesia according to the WHO are sepsis, prematurity, and asphyxia. A suboptimal hospital environment increases the risk of late-onset neonatal sepsis (LONS), which in turn can prolong hospital stays. Objective To assess for possible associations  of bacterial patterns in neonates with LONS, prematurity, and/or low birth weight. Methods Medical record data of 1,706 hospitalized neonates who were treated for sepsis or other disease in the Neonatal Unit, Dr. Cipto Mangunkusumo Hospital (CMH), Jakarta in 2020 were analyzed retrospectively. A total of 262 neonates had proven LONS. We assessed for possible risk factors such as gestational age, birth weight, and cultured blood microbes. Results Out of a total of 1,706 neonates admitted to the neonatal unit, the incidence of proven LONS was 15.4%. LONS was more prevalent (58.4%) in preterm than in full-term (41.6%) neonates. The majority (67.6%) of subjects with proven LONS were neonates with low birth weight (LBW) (<2,500 grams), and the largest percentage of them (35.1%) was in the 1,500-2,500-gram group. Gram negative bacteria emerged as the predominant pathogens of LONS patients in our hospital; the most common were Klebsiella pneumonia, Acinetobacter spp., Escherichia coli, Enterobacter spp., and Pseudomonas aeruginosa. Conclusion The proportion of LONS among LBW and preterm neonates is significantly higher compared to normal birth weight and  neonates. In our unit, LONS was mostly caused by Gram-negative bacteria. The antibiotic susceptibility of the various pathogens causing LONS in CMH should be tested and compared to the current empirical antibiotic guidelines used in CMH.
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
58
审稿时长
24 weeks
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