作为胰腺癌抗增殖剂的邻位二芳基吡唑甲酸乙酯类似物的合成与生物学评价

Q4 Chemistry

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI:10.14233/ajchem.2024.31173

Sandeep Singh, Rajeev Kumar Sharma, Aishwarya Singh, Manoj Garg, R. Ramajayam

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引用次数: 0

摘要

具有各种杂环的邻位二芳基支架显示出从抗菌到抗病毒的多种药理活性。在此，我们合成了以吡唑羧酸乙酯为中心环的新型邻位二芳基吡唑类似物，并评估了它们对胰腺癌细胞系 PANC-1 的抗增殖活性。在合成的 27 个化合物中，有 6 个化合物的抗增殖活性 IC50 值为个位数微摩尔。合成化合物的细胞毒性结果，尤其是化合物 25（IC50 = 4.8 µM），证实这些类似物可能需要进一步研究。

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Synthesis and Biological Evaluation of vicinal-Diaryl Pyrazole Ethyl Carboxylate Analogs as Antiproliferative Agent against Pancreatic Cancer

vicinal Diaryl scaffold possessing various heterocycles displayed versatile pharmacological activities ranging from antibacterial to antiviral. Herein, the synthesis of novel vicinal diaryl pyrazole ethyl carboxylate analogs as central ring and evaluated for their antiproliferative activity against pancreatic cancer line, PANC-1. Among the synthesized 27 compounds, six compounds displayed the IC50 value for antiproliferative activity in single digit micromolar. The cytotoxicity results of the synthesized compounds especially compound 25 (IC50 = 4.8 µM) confirms that these analogs may require further investigation.

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来源期刊

Asian Journal of Chemistry 化学-化学综合

CiteScore

0.80

自引率

0.00%

发文量

229

审稿时长

4 months

期刊介绍： Information not localized