5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids：合成和药物相似性建模

Molbank Pub Date : 2024-02-28 DOI:10.3390/m1779

Laura Giraldo-Arroyave, Andrés F. Yepes, Wilson Cardona-Galeano

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引用次数: 0

摘要

以点击化学为关键步骤，合成了一系列 5-氟尿嘧啶/香豆素和 5-氟尿嘧啶/色酮杂化物，并获得了良好的产率。通过光谱分析阐明了这些化合物和所有中间体的结构。此外，药代动力学和类药物计算结果表明，这些新型杂交化合物极有可能推进进一步的生物学研究。

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5-Fluorouracil/Coumarin and 5-Fluorouracil/Chromone Hybrids: Synthesis and Drug-Likeness Modeling

A series of 5-fluorouracil/coumarin and 5-fluorouracil/chromone hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds and all intermediates were elucidated by spectroscopic analysis. Furthermore, pharmacokinetic and drug-like computations taken together indicated that the novel hybrids have a strong possibility to advance to further biological studies.

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Molbank

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